The plasma 3H-radioactivity level showed a high value 1 hr after intra peritoneal injection of 3H-metaproterenol nd it l wered lineraly to reach 40% of the peak level 5 hr after administration. Radioactivity distributed to the kidneys and liver was markedly higher than that in other organs. Forty per cent of the amount given orally was excreted in the 24 hr urine specimen....

We used Daphnia magna bioassays to determine the LC(50) and the effects on the heart of the cardioactive drugs ouabain, verapamil, metaproterenol and metoprolol. Distinctions were made between the pharmacological and toxicological effects of these drugs and the adequacy of physicochemical characteristics of its habitat (reconstituted water). Video microscopy and digital image processing were us...

As previous studies have suggested that inhaled furosemide may have a protective effect against certain types of provocative challenges in asthmatic subjects, we investigated the role of furosemide in treating acute asthma exacerbations. Twenty-four patients (n = 24) with acute asthma were entered into the study on presenting to the emergency department. They were blindly randomized to receive ...

The acute respiratory distress syndrome (ARDS) is a disorder of diffuse lung injury secondary to a wide variety of clinical insults (eg, sepsis) and is manifested by impaired oxygenation, pulmonary edema, and decreased static and dynamic compliance. More recently, airflow resistance has been shown to be increased in humans with ARDS. We designed a prospective, randomized, placebo-controlled, cr...

The durations of action and side effects of four different pressurized bronchodilator aerosols were compared. One of the preparations contained isoprenaline alone, which was given in a dose of 400 /tg. The doses of the three other preparations were adjusted to yield nearly the same peak bronchodilator response as was obtained from 400 jtg isoprenaline. These doses differed from those yielded by...

OBJECTIVE To determine the effect of bronchodilator pretreatment on deposition uniformity of aerosolized pentamidine (AP) in HIV-positive patients who coughed while inhaling AP. DESIGN Nonrandomized control trial. SETTING A university hospital. PATIENTS Ten HIV-positive patients who were using AP prophylactically. INTERVENTION Four patients who coughed during AP administration were pret...

We assessed the bronchodilating effect of glycopyrrolate (GP) and compared it with that of metaproterenol (MP), alone and in combination (GP+MP), in patients with chronic obstructive pulmonary disease (COPD). In a double-blind study, 11 patients (aged (mean +/- SD) 69 +/- 6 yrs; forced expiratory volume in one second (FEV1) 1.2 +/- 0.4 L) with stable COPD inhaled nebulized GP 1.0 mg, MP 15 mg, ...

The prevalence of school absenteeism in asthmatic children has had little systematic attention from paediatricians, who are mainly concerned with the causation and treatment of this disease. This aspect clearly seems to be deserving of attention from a clinical viewpoint, and this paper summarizes some initial results which reveal that asthma is indeed a frequent cause of recurrent absence from...