Chromium (Cr) is an essential trace element for humans (Anderson, 1992) and laboratory animals (NRC, 1997). It is the trivalent form of the molecule that is active biologically, the hexavalent form is actually toxic to many animal cells (NRC, 1997). Chromium acts through a protein, once named glucose tolerance factor (GTF), now more commonly referred to as the glucose transporter. This protein ...

Creatine (Cr) is an important high-energy phosphate buffer in tissues with a high energy demand such as muscle and brain and is consequently a highly consumed nutritional supplement. Creatine is synthesized via the S-adenosylmethionine (SAM) dependent methylation of guanidinoacetate (GAA) which is not regulated by a feedback mechanism. The first objective of this study was to determine the effe...

Dietary restriction (DR), such as calorie restriction (CR) or methionine (Met) restriction, extends the lifespan of diverse model organisms. Although studies have identified several metabolites that contribute to the beneficial effects of DR, the molecular mechanism underlying the key metabolites responsible for DR regimens is not fully understood. Here we show that stimulating S-adenosyl-l-met...

The kinetics and thermodynamics of oxidation of Methionine and Ethionine by oxo (salen) chromium (V) ion have been investigated by spectrophotometric method in aqueous medium. The presence of water facilitates ligation of water to the Cr centre and forms an active oxidant [H2O (salen) Cr=O] + .The reaction is found to be first order each in the oxidant and the substrate. The presence of H + ion...

To determinate the effect of chromium-methionine level in diet on hatchability of Japanese quail in dry tropic weather under temperaturecontrolled in summer season, a completely randomized design experiment was conducted. Thousand two hundred eighty Japanese quail (960 females and 320 males), they were divided in 160 groups of eight (six females and two males), and were allocated in wire cages ...

The N-lobe of human serum transferrin (hTF/2N) and single point mutants in which each of the five methionine residues was individually mutated have been produced in a mammalian tissue-culture expression system. Since the five methionine residues are well distributed in the transferrin N-lobe, (13)C NMR of the [epsilon-(13)C]methionine-labelled proteins has been used to monitor conformational ch...

Oxidative damage in microbial cells occurs during exposure to the toxic metal chromium, but it is not certain whether such oxidation accounts for the toxicity of Cr. Here, a Saccharomyces cerevisiae sod1Delta mutant (defective for the Cu,Zn-superoxide dismutase) was found to be hypersensitive to Cr(VI) toxicity under aerobic conditions, but this phenotype was suppressed under anaerobic conditio...

Effects of sodium selenite (SS) in offspring of broiler breeders has been reported, but the comparison between SS and different level of methionine on offspring has received limited, so this study was conducted to investigate sodium selenite and methionine effects on concentration of selenium in egg and serum of Iranian native broiler breeders. An experiment was conducted in 3 × 3 factorial exp...

A feeding trial was carried out to determine the effects of chromium methionine (Cr-Met) chelate and forage level over two years, 1(st) fattening and 2(nd) fattening period on growth parameters, carcass characteristics and blood metabolites of 46 Korean native (Hanwoo, Bos Taurus, BW = 183 ± 44 kg) steers. Treatments were: 1) Steers in the low forage (LF) group were fed diets that consisted of ...