Osteosarcoma is the most common primary bone tumor in children and young adults. The median survival of osteosarcoma patients has not significantly improved since 1990, despite administration of different classes of chemotherapy agents, such as methotrexate, cisplatin and doxorubicin. Cancer stem cells (CSCs) are responsible for the resistance of osteosarcoma to chemotherapy and OCT4, SOX2 and ...

Objective: This report is of the experience with combination cyclophosphamide, methotrexate, and fluorouracil as adjuvant treatment for breast cancer at Tuen Mun Hospital. Patients and Methods: Records of patients who received combination cyclophosphamide, methotrexate, and fluorouracil chemotherapy during 1990 to 2000 were reviewed. Chemotherapy consisted of oral cyclophosphamide 100 mg/m on d...

•We report a choriocarcinoma coexisting with an epithelioid trophoblastic tumor.•Chemotherapy with methotrexate, etoposide, and actinomycin-D was efficacious.•Choriocarcinoma with epithelioid trophoblastic tumor may benefit from chemotherapy.

background : gestational trophoblastic neoplasia (gtn) refers to malignant lesions that arise from abnormal proliferation of placental trophoblast. even in its metastatic forms gtn is curable with a cure rate of 90-100 %. currently, methotrexate with or without folic acid, andactinomycin d is recommended for low risk gtn. the aim of this study is to compare the efficacy of methotrexate and acti...

Methotrexate is a type of disease-modifying anti-rheumatic drug (DMARD). It used to reduce activity the immune system for people who have certain conditions. chemotherapy agent and suppressant. Its use may be limited by concerns regarding its adverse reactions. The occurrence reactions in some cases leads therapy discontinuation. Although (ADR) methotrexate generally do not pose serious threat ...

Rationale: Leukoencephalopathy, a complication associated with chemotherapy has been reported after giving high doses of methotrexate and cytarabine no specific risk factors to date. Objectives: To review the prevalence chemotherapy-induced leukoencephalopathy in children acute lymphoblastic leukemia (ALL). present clinical course, pathogenesis neuro-imaging findings ALL. Case: We three cases a...

A 63-year-old female patient who had undergone cholecystectomy for inflammatory myofibroblastic tumor (IMT) in the gallbladder was referred to our hospital. The patient's disease relapsed, involving the pancreas, and was diagnosed as inoperable IMT 13 months after the cholecystectomy. The patient failed to respond to steroid and non-steroidal anti-inflammatory drug therapy, but subsequently exh...

  Background : Gestational trophoblastic neoplasia (GTN) refers to malignant lesions that arise from abnormal proliferation of placental trophoblast. Even in its metastatic forms GTN is curable with a cure rate of 90-100 %. Currently, methotrexate with or without folic acid, andactinomycin D is recommended for low risk GTN. The aim of this study is to compare the efficacy of methotrexate and ac...

Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a s...

Spontaneously occurred canine mammary tumours (55) were treated with chemotherapy (Methotrexate), combination chemotherapy with COX-2 inhibitor (Meloxicam) and by surgical therapy. In chemotherapy groups Hb and TEC values reduced significantly (P<0.05) from the base line value at 3rd week of therapy. Histologically, benign and malignant mixed mammary tumours were predominant. Methotrexate and C...