Introduction: Definite Meniere's diseaseis associated with two or more definitive periods of vertigo along with hearing loss, plus tinnitus or aural fullness or both. This study aimed to compare the effect of intratympanic dexamethasone and methylprednisolone on the functional-level scale of pure-tone audiometry (PTA), and class outcome measures of vertigo.  Materials and Methods: In this clini...

The repair of peripheral nerve injuries is still one of the most challenging tasks and concerns in neurosurgery. Effect of methylprednisolone-laden hydrogel loaded into a chitosan conduit on the functional recovery of peripheral nerve using a rat sciatic nerve regeneration model was assessed. A 10-mm sciatic nerve defect was bridged using a chitosan conduit (CHIT/CGP-Hydrogel) filled with CGP-h...

background:   objective: it was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine.   materials and methods: bone mineral density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (alp) measurements were performed. o...

Although the main hematologic findings, such as spherocytosis, polychromasia, anisopoikilocytosis, and reticulocytosis, etc. and Coombs test results were not given, the patient most likely had hemolytic anemia, for which he was given pulse methylprednisolone (MP) three days after intravenous immunoglobulin (IVIG) therapy, which might also cause encephalopathy. However, the hematologic changes w...

background: to manage relapsing‑remitting multiple sclerosis (ms) in the course of acute exacerbations, methylprednisolone (mp) (medrol or solu‑medrol), has the ability to lock the injured blood‑brain barrier and decrease irritation in the central nervous system. the aim of this preliminary study was to investigate the frequency and time interval related to mp pulse therapy in patients with ms....