The K4a surface efflux from the cat neocortex and rat hippocampus was studied after preloading with K”a from the surface. This K4s efflux increases from two to nine times during or after all electrically or Metrazol-induced seizures and “spontaneous” seizures. The K4s influx does not change during a seizure, so this increased efflux is not due to change in the diffusion constant or water flow f...

Germ-free mice were found to be more sensitive than conventional mice to poisoning by hemicholinium-3, hexamethonium chloride, strychnine sulfate, sodium pentobarbital, sodium barbital, and histamine diphosphate. On the other hand, conventional mice were more sensitive to atropine. No difference between germ-free and conventional mice was found in sensitivity to d-tubocurarine, metrazol, and pi...

2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, (1)H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized comp...

Previous research demonstrated that following amygdala kindling, animals showed a heightened sensitivity to morphine's convulsive effects and an exaggerated Straub tail response. These effects were evident to 3 months after their last convulsion and could be blocked by naloxone pretreatment. The present paper extends these findings by demonstrating that animals given metrazol or electroshock (E...

objective: newbouldia laevis seem, is an ubiquitous perennial plant belonging to the family bignoniaceae with varying applicability in ethnomedicine. methods: the anticonvulsant effect of the aqueous extracts of root and stem bark preparations was undertaken using standard techniques. results: results showed that the ld50 in mice was 489.8mg/kg body weight while 5.6mg/kg body weight protected m...