ISO/IEC has issued several International Standards concerning the concept of traceability in laboratory medicine. prEN ISO 17511 Metrological traceability of values assigned to calibrators and control materials, prEN ISO 18153 Metrological traceability of values for catalytic concentrations of enzymes assigned to calibrators and control materials, prEN ISO 15193 Presentation of reference measur...

At the start of the 21st century, a dramatic change occurred in the clinical laboratory community. Concepts from Metrology, the science of measurement, began to be more carefully applied to the in vitro diagnostic (IVD) community, that is, manufacturers. A new appreciation of calibrator traceability evolved. Although metrological traceability always existed, it was less detailed and formal. The...

The paper describes the metrological hierarchy established for the dissemination of angle measurements from the “Dimensional Metrology Laboratory” (LAMIN) of the “National Institute of Metrology, Standardisation and Industrial Quality” (INMETRO). It shows the traceability chain from the national standard of length to the reference system, a small angle generator, and then to angle standards and...

Mauro Panteghini*, Ian S. Young and Philippe Gillery on behalf of the IFCC Scientific Division 1 Department of Clinical Sciences ‘‘Luigi Sacco’’ and Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy 2 Department of Medicine, Wellcome Research Laboratories, Royal Victoria Hospital, Belfast, UK 3 Laboratoire de Biologie et de Recherche Pédiatri...

The fluorine content of polymer particles labelled with 2,2,2-trifluoroethylamine was reliably quantified with overlapping sensitivity ranges by XPS and solid-state NMR. This provides a first step towards reference materials for the metrological traceability of surface group quantifications. The extension of this concept to fluorescence spectroscopy is illustrated.

W. Garry John, Gunnar Nordin and Mauro Panteghini* 1 Clinical Biochemistry, Norfolk and Norwich University Hospital, and School of Medicine, Health Policy and Practice, UEA, Norwich, NR4 7UY, UK 2 External Quality Assurance in Laboratory Medicine in Sweden, Uppsala, Sweden 3 Centre for Metrological Traceability in Laboratory Medicine (CIRME) and Department of Clinical Sciences ‘‘Luigi Sacco’’, ...

Mauro Panteghini* and W. Garry John on behalf of the IFCC Scientific Division 1 Centre for Metrological Traceability in Laboratory Medicine (CIRME), University of Milan, Milan, Italy 2 Department of Clinical Sciences ‘‘Luigi Sacco’’, University of Milan, Milan, Italy 3 Clinical Biochemistry, Norfolk and Norwich University Hospital, and School of Medicine Health Policy and Practice, UEA, Norwich...