نتایج جستجو برای: mexz
تعداد نتایج: 21 فیلتر نتایج به سال:
Cystic fi brosis 40 Aminoglycoside resistance of Pseudomonas aeruginosa in cystic fi brosis results from convergent evolution in the mexZ gene M H Prickett, A R Hauser, S A McColley, J Cullina, E Potter, C Powers, M Jain OPEN ACCESS Lung cancer 48 Final screening round of the NELSON lung cancer screening trial: the effect of a 2.5-year screening interval U Yousaf-Khan, C van der Aalst, P A de J...
Messadi AA, Lamia T, Kamel B, Salima O, Monia M, Saida BR. Association between antibiotic use and changes in susceptibility patterns of Pseudomonas aeruginosa in an intensive care burn unit: a 5-year study, 2000-2004. Burns :J Int Soc Burn Injuries 2008;34(8):1098-102. Sherertz RJ, Sarubbi FA. A three-year study of nosocomial infections associated with Pseudomonas aeruginosa. J Clin Micr...
A mutant, named 11B, hypersusceptible to aminoglycosides, tetracycline, and erythromycin was isolated after Tn501 insertion mutagenesis of Pseudomonas aeruginosa PAO1. Cloning and sequencing experiments showed that 11B was deficient in an, at that time, unknown active efflux system that contains homologs of MexAB. This locus also contained a putative regulatory gene, mexZ, transcribed divergent...
Background: Pseudomonas aeruginosa is the main pathogen responsible for lung destruction in cystic fibrosis, becoming difficult to eradicate chronic infection. Aims: To describe antibiotic resistance among strains of P.aeruginosa isolated from sputa patients with fibrosis. investigate vivo and vitro expression genes related anaerobic growth. Methods: Sputa (in vivo) vitro) 26 were obtained duri...
The majority of cystic fibrosis (CF) patients succumb to a chronic infection of the airway with Pseudomonas aeruginosa. Paradoxically, pathogenic strains are often susceptible to antibiotics, but the infection cannot be eradicated with antimicrobial therapy. We find that in a majority of patients with airway infections, late isolates of P. aeruginosa produce increased levels of drug-tolerant pe...
BACKGROUND Small colony variants (SCVs) are slow-growing bacteria, which often show increased resistance to antibiotics and cause latent or recurrent infections. It is therefore important to understand the mechanisms at the basis of this phenotypic switch. METHODOLOGY/PRINCIPAL FINDINGS One SCV (termed PAO-SCV) was isolated, showing high resistance to gentamicin and to the cephalosporine cefo...
When bacteria evolve resistance against a particular antibiotic, they may simultaneously gain increased sensitivity against a second one. Such collateral sensitivity may be exploited to develop novel, sustainable antibiotic treatment strategies aimed at containing the current, dramatic spread of drug resistance. To date, the presence and molecular basis of collateral sensitivity has only been s...
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