Metronidazole is used to treat trichomoniasis, bacterial vaginosis, and other diseases. There are controversy aspects about its teratogenicity. A teratogenic agent can alter morphology or subsequent function of the fetus. The aim of this study was to examine an alternative method for the recognition of the mechanism or the bimolecular potential changes in mice fetus caused by Metronidazole usin...

Azole agents especially Miconazole are widely used even during pregnancy as antifungal agents. The aim of this study was to assess the usefulness of FTIR Micro-Spectroscopy for discriminating of Miconazole treated liver tissue from control liver tissue. The mice were injected with Miconazole (60 mg/Kg) on gestation day 9 and they were dissected on pregnancy day 15. The fetus fixed, dehydrated, ...

Adult pregnant mice were given i.v. injections of (3H)3-methylcholanthrene (20 muCi in 1.1 mug/mouse) or (14C)3-methylcholanthrene (1.0 muCi in 48 mug/mouse). Ethanol extracts of their tissues were chromatographed on Sephadex LH-20. Three groups of 3-methylcholanthrene metabolites were obtained: one group as yet unidentified, one containing the hydrocarbon and hydroxylated derivatives, and a th...

vitex agnus castus (chasteberry) is a popular treatment for the management of female reproductive disorders including corpus luteum insufficiency, premenstrual syndrome (pms), menopausal symptoms, and insufficient milk production. according to developing situation of complementary medicine, and frequent use of this herb, it is important to examine its effects during pregnancy. in this research ...

Background: Cutaneous leishmaniasis is a common parasitic disease in Iran being mainly caused by Leishmania (L.) major. The aim of this study was to investigate the occurrence of apoptosis in the spleen and liver of female mice infected with L. major.Methods: BALB/c mice were randomly assigned into the control and experimental groups (ten mice per group). The experimental groups were subcutaneo...

quantum dots are new types of fluorescent materials for biological labeling. as a result, qds toxicity study is an essential requirement for future clinical applications. therefore, the cytotoxic cdse:zns quantum dots effects on some organs in mice are presented in this study. in this work, 10, 20 and 40 mg/kg doses of cdse:zns quantum dots were injected to 32 adult male mice. structural and op...

background: methamphetamine (ma) is a potent psychomotor stimulant with high abuse and addictive potential. ma is a neurotoxic drug which is widely abused by females of childbearing age, raising serious public health concerns in terms of exposure of the fetus to the drug. neurotoxic effects of ma on adult are well known, such as dopaminergic nerve terminal degeneration and cell death in regions...

Abstract The proper functional interaction between different tissues represents a key component in systemic metabolic control. Indeed, disruption of endocrine inter-tissue communication is hallmark severe dysfunction obesity and diabetes. Here, we show that the FNDC4-GPR116, liver-white adipose tissue axis controls glucose homeostasis. We found liver primarily controlled circulating levels solu...

abstract since gasoil due to the aromatics of the most important environmental pollutants and is one of the oil with many applications. according to its damaging effects on living organisms and human beings, the purpose of this study was to investigate the effects of gasoil on the parameters of liver, white rat race was albino nmri. the 40 mice in 4 groups, adult male mice were divided into con...

The distribution of 14C-styrene was studied in the pregnant mouse using a whole body low temperature autoradiographic technique. In unsectioned tissues studied by liquid scintillation the concentrations of styrene and its metabolites in maternal and fetal blood and organs and in the placenta and amniotic fluid were determined. The organs which had higher concentrations of volatile styrene were ...