The dehydrobromination reaction 2-(p-nitrophenyl)ethyl bromide + OH⁻ was investigated in several alkanediyl-α-ω-bis(dodecyldimethylammonium) bromide, 12-s-12,2Br⁻ (with s = 2, 3, 4, 5, 6, 8, 10, 12) micellar solutions, in the presence of NaOH 5 × 10⁻³ M. The kinetic data were quantitatively rationalized within the whole surfactant concentration range by using an equation based on the pseudophas...

I.F. Uchegbu et al. (eds.), Fundamentals of Pharmaceutical Nanoscience, DOI 10.1007/978-1-4614-9164-4_2, © Springer Science+Business Media New York 2013 Abstract Low molecular weight amphiphile micelles are formed from the selfassembly of comparatively hydrophilic amphiphiles (molecular weight <1,500 Da). These structures may be spherical or present as nanofi bres in the case of peptide amphiph...

Micellar solubilization is a powerful alternative for dissolving hydrophobic compounds in aqueous environment. Fluorescence and absorption spectroscopy are the two techniques used to monitor the micellar solubilization studies of p-amino benzoic acid (PABA). PABA is an aromatic compound with acidic functional group, is non essential nutrient, used as a sunscreen. Externally, it prevents sunburn...

Abbreviations MLC micellar liquid chromatography FDA food and drug analysis 2 Abstract A simple and robust method was developed for the routine identification and quantification of amoxicillin by micellar liquid chromatography. Amoxicillin, a β-lactamase inhibitor, is one of the most commonly prescribed drugs in the treatment of urine and skin structure infections. In this work, amoxicillin was...

A green and convenient méthode for the synthesis of  a variety of xanthene derivatives by condensation reaction between aldehydes and β-naphthol or dimedone in an micellar solution of sodium dodecylphosphonate is described. This method offers several advantages, such as using of a cheap and environmentally benign reaction media, low loadings of sodium dodecylphosphonate as catalyst and...

Solubility of 2,6-diphenyl-4-(2,4,6-triphenylpyridinium-l-yl) phenolate, commonly known as Reichardt' s betaine dye and a ketocyanine dye has been determined in binary solvent mixtures and in cationic and anionic micellar media. In all the binary mixtures the standard molar free energy of solution, as given by log Sl2 where 512 is the solubility in the binary mixture, cannot be represented by t...

Dissolution behaviour of pure cefprozil monohydrate (CM) and cefuroxime axetile (CA) and their marketed tablets have been studied in aqueous as well as micellar media. Dissolution of cefprozil monohydrate is significantly assisted in presence of sodium dodecyl sulphate (SDS) and cetyltrimethylammonium bromide (CTAB). But, SDS and CTAB behave differently in accelerating the dissolution tendency ...

A partial least-squares regression (PLS) was developed for the simultaneous spectrophotometric determination of aluminum and beryllium in geochemical samples by xylenol orange as the chromogenic reagent in water media and in micellar media. The effects of pH, xylenol orange concentration and surfactant concentration on the complexes formation reactions were studied. In the absence of surfactant...

Catalytic and spectroscopic properties of alcohol dehydrogenase from horse liver, incorporated in reversed micellar media, have been studied. Two different reversed micellar systems have been used, one containing an anionic [sodium bis(2-ethylhexyl)sulfosuccinate, AOT], the other containing a cationic (cetyltrimethylammonium bromide, CTAB) surfactant. With 1-hexanol as substrate the turnover nu...

The use of micellar media in constant-energy synchronous fluorescence spectrometry has been proposed. The influence of some aqueous micellar systems on the determination of pyrene, perylene and benzo[a]pyrene has been investigated. The presence of these micellar systems allows their determination in aqueous media, thus avoiding the use of an organic solvent, and greatly enhances the fluorescenc...