OBJECTIVE Druggability of a target protein depends on the interacting micro-environment between the target protein and drugs. Therefore, a precise knowledge of the interacting micro-environment between the target protein and drugs is requisite for drug discovery process. To understand such micro-environment, we performed in silico interaction analysis between a human target protein, Dipeptidyl ...

BACKGROUND Characteristics of the physical environment can be classified into two broad categories: macro- ("raw" urban planning features influenced on a regional level) and micro- (features specifically within a streetscape influenced on a neighborhood level) environmental factors. In urban planning applications, it is more feasible to modify conditions at the neighborhood level than at the re...

BACKGROUND Increasing participation in transportation cycling represents a useful strategy for increasing children's physical activity levels. Knowledge on how to design environments to encourage adoption and maintenance of transportation cycling is limited and relies mainly on observational studies. The current study experimentally investigates the relative importance of micro-scale environmen...

Micro-manufacturing emerged in the last years as a new engineering area with the potential of increasing peoples’ quality of life through the production of innovative micro-devices to be used, for example, in the biomedical, micro-electronics or telecommunication sectors. The possibility to decrease the energy consumption makes the micro-manufacturing extremely appealing in terms of environment...

Abstract Environmental Justice (EJ) concept consists of multifaceted movements, community struggles, and discourses in contemporary societies that seek to reduce environmental risks, increase environmental protections, and generally reduce environmental inequalities suffered by minority and poor communities a term that incorporates ‘environmental racism’ and ‘environmental classism,’ captures ...

The specific aim of this study was to develop a pH independent controlled release system for the basic drug, theopylline. The release of the drug was investigated in vitro from hydrophilic swellable matrices composed of hydroxyethyl cellulose and Eudragit S100. The micro-environmental pH of the hydrated gel layer of the matrices was manipulated by the addition of fumaric acid. It is expected th...

many pieces of research have investigated the environmental variable including environmental beliefs, values, attitudes, knowledge, and behaviors among iranian people, but their coverage has not gone beyond a few provinces. this research investigates the status of iranian's environmental values (in micro and macro level) in national level and gone beyond description by targeting explanatio...

Historically LCA has mainly been applied to products; however, it can be very useful in assisting the whole product development by identifying more sustainable options in process selection, design and optimisation. It has been shown that it is relevant to apply LCA to micro components and more specifically to the research area of micro manufacturing where both processes and products are stated ...

Soil contains almost twice as much carbon (C) as the atmosphere and 5-15% of soil C is stored in a form of particulate organic matter (POM). Particulate organic matter C is regarded as one of the most labile components of the soil C, such that can be easily lost under right environmental settings. Conceptually, micro-environmental conditions are understood to be responsible for protection of so...