Diabetic retinopathy is the leading cause of blindness in the western working age population and microaneurysms are one of the first pathologies associated with diabetic retinopathy. We have developed a prototype microaneurysm detection system for non-mydriatic colour fundus images. Candidate microaneurysms are located by a standard method that enhances small round features after background int...

Diabetic retinopathy is characterized by the development of retinal microaneurysms. The damage can be prevented if disease is treated in its early stages. In this paper, we are comparing Support Vector Machine (SVM) and Naïve Bayes (NB) classifiers for automatic microaneurysm detection in images acquired through non-dilated pupils. The Nearest Neighbor classifier is used as a baseline for compa...

In this paper, we present an approach to improve microaneurysm detection in digital color fundus images. Instead of following the standard process which considers preprocessing, candidate extraction and classification, we propose a novel approach that combines several preprocessing methods and candidate extractors before the classification step. We ensure high flexibility by using a modular mod...

BACKGROUND Although microaneurysms are a clinicopathological hallmark of diabetic retinopathy, there have been few ultrastructural studies of these important lesions. As a result, knowledge of the mechanisms involved in the pathogenesis of microaneurysms remains fragmentary. This study provides histological and ultrastructural evidence of various stages in microaneurysm formation within the ret...

This paper presents a new approach to the computer aided diagnosis (CAD) of diabetic retinopathy (DR)—a common and severe complication of long-term diabetes which damages the retina and cause blindness. Since microaneurysms are regarded as the first signs of DR, there has been extensive research on effective detection and localization of these abnormalities in retinal images. In contrast to exi...

Diabetic retinopathy has been examined in dogs made diabetic by bovine growth hormone or alloxan, and in humans. The thin-walled microaneurysm is a simple expansion of the circumference of the capillary with basement membrane thickening. The thick-walled microaneurysm represents the deposition of considerable debris between layers of thickened basement membrane, as well as compression phenomeno...

The authors present the role of VEGF in microaneurysm formation, blood-retinal barrier breakdown, development of capillary nonperfusion and retinal neovascularization in pathogenesis of diabetic retinopathy. Inhibitors of VEGF in treatment of diabetic retinopathy are presented.