dna microarray is a powerful approach to study simultaneously, the expression of 1000 of genes in a single experiment. the average value of the fluorescent intensity could be calculated in a microarray experiment. the calculated intensity values are very close in amount to the levels of expression of a particular gene. however, determining the appropriate position of every spot in microarray im...

background: one substantial part of microarray studies is to predict patients’ survival based on their gene expression profile. variable selection techniques are powerful tools to handle high dimensionality in analysis of microarray data. however, these techniques have not been investigated in competing risks setting. this study aimed to investigate the performance of four sparse variable selec...

this review deals with studies that have used cdna microarrays and immunohistochemistry to identify a subtype of breast carcinoma recently known as “basal-like” carcinoma. the key breast carcinoma studies are critically discussed to highlight methodological problems in cohort selection, definitions, interpretation of results, and statistical analysis. it concludes that “basal-like” carcinomas d...

microarray data have an important role in identification and classification of the cancer tissues. having a few samples of microarrays in cancer researches is always one of the most concerns which lead to some problems in designing the classifiers. for this matter, preprocessing gene selection techniques should be utilized before classification to remove the noninformative genes from the microa...

the dna microarray is an important technique that allows researchers to analyze many gene expression data in parallel. although the data can be more significant if they come out of separate experiments, one of the most challenging phases in the microarray context is the integration of separate expression level datasets that have gathered through different techniques. in this paper, we present a...

Background: Maternal mRNA degradation is a selective process that occurs in waves corresponding to important developmental transitions such as resumption of meiosis, fertilization and zygotic genome activation. It has been demonstrated that the number, position, and combination of 3 UTR cis-acting elements interacting with trans-acting protein factors regulate translation and mRNA stability. Ou...