Biologically triggered exploding microcapsules were synthesized by layer-by-layer assembly of biopolymers. The microcapsules showed controlled rupturing behaviour upon exposure to a pathologically relevant biomolecule, trypsin. These microcapsules offer significant potential for clinical applications.

Intense emission peaks of Eu(DBM)3Phen (DBM and Phen are dibenzoylmethane and 1,10phenanthroline, respectively) in the microcapsules containing molecules of quaternary ammonium chitosan (QACS) and sodium alginate are observed. The microcapsules are assembled by using CaCO3 particles as template cores by the layer-by-layer (LbL) technique. Observation of microcapsules by the fluorescence mode an...

Polyurea microcapsules containing 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide as the active agent were prepared by the method of interfacial polycondensation with methylene bis(phenyl isocyanate) as the multifunctional isocyanate, hexamethylene diamine as the diamine, and anionic sodium lignin sulphonate as the emulsifying agent . Thermal stability of the microcapsules was investi...

In this work, 1.4 mm dibutylphthalate (DBP) filled urea–formaldehyde (UF) microcapsules were used as Pickering stabilizers to create larger 140 mm microcapsules containing a second liquid phase, dicyclopentadiene (DCPD). The binary microcapsules were made by encapsulating the dispersed DCPD liquid (stabilized with the UF(DBP) microcapsules in water) via an isocyanate–alcohol interfacial polymer...

Here we describe the preparation of BSA-FITC-loaded microcapsules as a model protein system for in vivo delivery. BSA-FITC-loaded microcapsules were prepared using a mono-axial nozzle ultrasonic atomizer, varying a number of parameters to determine optimal conditions. The preparation method chosen resulted in a BSA-FITC encapsulation efficiency of approximately 60% and a particle size of approx...

This paper presents a novel microcompartmentalized reaction system for cell-free protein synthesis using semi-permeable microcapsules. We used a microfluidic device to encapsulate template DNA and enzymes for cell-free protein synthesis into semi-permeable microcapsules composed of alginate and polyethylene imine (PEI). The template DNA was encapsulated into individual microcapsules at the conc...

The aim of this study is to explore an improved double emulsion technology with in situ reaction of lysine (Lys) and glutaraldehyde (GA) for fabricating autofluorescent Lys-poly(lactic-co-glycolic acid)-GA (Lys-PLGA-GA) microcapsules as novel ultrasonic/fluorescent dual-modality contrast agents. Scanning electron microscope (SEM) and static light scattering (SLS) results show that 80% of the Ly...

A new, novel promising technology for obtaining controlled release and enhancing the bioavailability is a combination of mucoadhesion principle and microencapsulation to result in mucoadhesive microcapsules. Mucoadhesive microcapsules consist of either entirely of a mucoadhesive polymer or having an outer coating enclosing the drug particles. They facilitate an intimate and prolonged contact wi...

BACKGROUND In this study, 293T cells were genetically engineered to secrete tissue inhibitor of metalloproteinase-2 (TIMP2) and encapsulated into alginate microcapsules to continuously release TIMP2 protein. METHODS The anti-invasive potential of the microcapsules was studied in vitro using brain tumor cells. The TIMP2 gene was transfected to 293T cells, and genetically engineered 293TIMP2 ce...

Microencapsulation of insulin has been difficult, due to the high sensitivity of insulin to the harsh conditions that can occur during the microencapsulation process. We have developed a method of preparing insulin-loaded microcapsules by using a monoaxial ultrasonic atomizer to form microdroplets of insulin in aqueous solution surrounded by poly(lactic-co-glycolic acid) (PLGA) solution. Admini...