In the present work glipizide based microemulsion was developed and its usefulness as topical drug carrier system for the non-insulin dependent diabetes mellitus (NIDDM) was investigated. Microemulsion was prepared by water titration method using oleic acid as oil phase, tween-80 as surfactant and propylene glycol as co-surfactant. Menthol as a permeation enhancer was added to a final drug-load...

OBJECTIVE The purpose of this study was to improve skin permeation of evodiamine and rutaecarpine for transdermal delivery with microemulsion as vehicle and investigate real-time cutaneous absorption of the drugs via in vivo microdialysis. METHODS Pseudoternary phase diagrams were constructed to evaluate microemulsion regions with various surfactants and cosurfactants. Nine formulations of oi...

Microemulsions improve the transdermal delivery of several drugs over conventional topical preparations such as emulsions and gels: enhanced drug solubilization, increased skin flux, decreased diffusion coefficient. Microemulsion-based systems find significant improvement in antifungals. We believe that drug-loaded microemulsion will show better antifungal activity by penetration into fungal ce...

The objective of the present study was to examine the influence of cosolvent system and microemulsion formulation on in-vitro skin permeation of gabapentin, furthermore, to characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) cremophor 40-based microemulsions in comparison to the blank counterparts. The cosolvent system prepared by homogenous mixi...

The purpose of this study was to investigate microemulsions as delivery systems for diclofenac sodium (DS). Microemulsion systems were composed of: soybean oil, nonionic surfactants (Brij 58 and Span 80), and different alcohols: ethanol, and 1-buthanol as cosurfactant. The optimum surfactant: cosurfactant (S:CoS) weight ratios and microemulsion areas were detected by the aid of ternary phase di...

background the development of drug delivery systems has improved the therapeutic and toxic properties of existing drugs in therapy. microemulsion systems are novel vehicles for drug delivery, which have been developed in recent years. these systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating ...

The novel carriers have been exploited through almost all the routes of administration. Association of drugs with carriers is normally noncovalent, based on collective strength of weak binding forces. Many newer carriers are evolving with the advent of technology and the demand of targeted delivery like microemulsions. Microemulsions are clear, stable, isotropic mixtures of oil, water and surfa...

The aim of this study was to evaluate the vehicle effect on in vitro diffusion of Diphenhydramine hydrochloride (DPH) from new five topical formulations: microemulsion (A), microemulsion+silica (B), Na Alginate emulgel (C), Carbopol cream (D) and hydroxyethylcellulose gel (E).Furthermore, the skin irritation potential and the formulation effect on skin reaction induced by histamine were investi...

Purpose: To measure the extent of solubility of the lipophilic drug, aceclofenac, in 13 oils as well as its in vitro permeability from these oils in order to develop optimized topical microemulsion and microemulsion-based gel for improved bioavailability. Methods: UV spectrophotometeric method was used at the wavelength of 276 nm to measure the dissolved quantity of aceclofenac in each of the o...