During last two decades, polysaccharides such as alginate (Alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. The aim of the present work was to investigate the potential utility of microparticles made of alginate (Alg) as new vehicles for improving nasal vaccine delivery. For this purpose, diphtheria toxoid (DT) was chosen as a model an...

inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. the present study is concerned with the development and characterization of a novel, spray dried, aerosolized, chitosan polyelectrolyte complex (pec) based microparticles containing antibacterials for the treatment of lung infections.chitosan polyelectrolyte complex...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

objectives: platelets are anucleated fragments derived from megakaryocytes. it has been demonstrated that platelets play a role in hemostasis and innate immunity. in addition, platelets have a cd40 ligand which is an important molecular marker in motivating immune cells. thus, platelets also have a role in adaptive immunity as seen by their ability to activate b cells. since human platelet micr...

here we report a novel approach for preparation of a 6-day transdermal drug delivery system (tdds) as treatment for mild to moderate alzheimer’s disease. the spray drying method was used to prepare microparticles containing the anti-alzheimer drug. the content of the drug was determined by high performance liquid chromatography (hplc) method. the morphology and size range of the microparticles ...

OBJECTIVES In this study, we evaluated the cellular origins and thrombogenic potential of microparticles. BACKGROUND Human atherosclerotic plaques contain submicron vesicles (microparticles) released during cell activation or apoptosis. METHODS Microparticles were purified from plaques and platelet-free plasma from 26 patients undergoing carotid endarterectomy. Flow cytometry analysis revea...

This article describes the preparation and characterization of anticancer drug-loaded poly(lactide-coglycolide) (PLGA) microparticles. PLGA microparticles loaded with doxorubicin HCl (DOX) were prepared via o/w emulsion solvent evaporation. The release characteristics, encapsulation efficiency, size, and morphology of the PLGA microparticles were also determined. A cytotoxicity test was perform...

Platelet microparticles are a normal constituent of circulating blood. Several studies have demonstrated positive correlations between thrombotic states and platelet microparticle levels. Yet little is known about the processes by which platelet microparticles are generated in vivo. We now characterize microparticles derived directly from megakaryocytes. Video microscopy of live mouse megakaryo...

OBJECTIVE Microparticles are small, membrane-coated vesicles that can serve as novel signaling structures between cells. The aim of the present study was to analyze the profile of microparticles in the blood of patients with systemic sclerosis (SSc; scleroderma) and healthy controls. METHODS The study population consisted of 37 patients with SSc and 15 healthy subjects of comparable sex and a...

BACKGROUND We recently assigned a new fibrinolytic function to cell-derived microparticles in vitro. In this study we explored the relevance of this novel property of microparticles to the in vivo situation. DESIGN AND METHODS Circulating microparticles were isolated from the plasma of patients with thrombotic thrombocytopenic purpura or cardiovascular disease and from healthy subjects. Micro...