Transdermal drug delivery system (TDDS) is not practicable for delivery of materials whose final target is skin itself. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is a challenging area of research. Microsponges are highly porous micro-sized particles with a unique abil...

Nanosponge and Microsponge delivery System was originally developed for topical delivery of drugs can also be used for controlled oral delivery of drugs using water soluble and bioerodible polymers. It holds a promising future in various pharmaceutical applications in the coming years like enhanced product performance and elegancy, extended release, reduced irritation, improved thermal, physica...

Invasive fungal infections can be devastating, especially in immunocompromized patients. Oral administration of fluconazole (FLZ) often produces gastric irritation, heart-burn, vomiting and sometimes patient can develop ulceration resulting in a less patient compliance with long term therapy. The aim of the present study was to formulate topical microsponge-based delivery system containing FLZ ...

In pharmaceutical industry, various controlled released dosage forms like solid formulation, semi solid formulation and topical preparation have more importance due to efficacy and patient compliance. Topical preparations have some disadvantages like unpleasant odour, greasiness and skin irritation and fail to reach the systemic circulation in sufficient amounts in few cases. This problem is ov...

Background: Microsponge is a class of dosage form containing porous nature drug that targeted to achieve sustained action for prolong period. based delivery system results in localization on skin surface and epidermis without moving systemic circulation higher extent. Methods: Present study aims formulate the microsponge celecoxib by quasi emulsification solvent diffusion method. Prepared formu...

The technology of drug delivery has become massively competitive and quickly growing. Enhancing efficacy is the primary objective system development, hence cost-effectiveness treatment. 
 Nevertheless, controlling rate active pharmaceutical moieties to a target site within body been one major obstacles confronted by industry. Microsponge represents considered promising innovation that over...