نتایج جستجو برای: microtubuleassociated protein2
تعداد نتایج: 192 فیلتر نتایج به سال:
Members of the MARK subfamily of the CaMK protein kinases phosphorylate microtubuleassociated proteins tau, MAP2, and MAP4 which are involved in the regulation of the cytoskeleton and the microtubule-based transport by motor proteins of the kinesin family [1]. Hyperphosphorylation of neuronal tau by MARK is a potential cause for the aggregation of tau and the formation of paired helical filamen...
OBJECTIVE The Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) is a scaffolding protein known to regulate ion homeostasis in the kidney and intestine. Previous work showed that EBP50 expression increases after balloon injury in rat carotids. This study was designed to determine the role of EBP50 on vascular smooth muscle cells (VSMC) proliferation and the development of neointimal hyperpl...
Calcium/calmodulin-dependent protein kinase II (CaMKII) is a ubiquitous enzyme, present in essentially every tissue but most concentrated in brain. It is a multifunctional Ca 2 /calmodulindependent protein kinase capable of phosphorylating protein substrates, such as AMPA receptors, synapsin I, tyrosine hydroxylase, L-type Ca 2 channels, and MAP-2 (microtubuleassociated protein 2), substrates t...
Classical physiological experiments identified cAMP as a diffusible intracellular secondary messenger capable of activating cAMP-dependent protein kinase (PKA). These studies defined hormoneand location-specific patterns of PKA activation, suggesting that PKA signaling was compartmentalized. For example, in perfused rat cardiomyocytes, adrenergic stimulation selectively activates a pool of PKA ...
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