Background: A canine is classified as "transmigrated" when it crosses the midline. Transmigration of mandibular canines bilaterally an extremely rare developmental dental ectopia with obscure etiology. Case Description:A 13 year old female and 10 male patient reported to department chief complaint missing teeth in upper front region retained deciduous tooth lower respectively. Panoramic radiogr...

Orofacial clefts are one of the most common congenital anomalies. The incidence is approximately 1 : 500 to 1 : 550 births [1]. The group of orofacial anomalies is heterogeneous. It comprises “typical” orofacial clefts ((cleft lip (CL), cleft lip and cleft palate (CLP) and cleft palate only (CP)) and “atypical” clefts (median, transversal, oblique and other Tessier’s types of facial clefts)[1]....

Orofacial clefts are one of the most common congenital anomalies. The incidence is approximately 1 : 500 to 1 : 550 births [1]. The group of orofacial anomalies is heterogeneous. It comprises “typical” orofacial clefts ((cleft lip (CL), cleft lip and cleft palate (CLP) and cleft palate only (CP)) and “atypical” clefts (median, transversal, oblique and other Tessier’s types of facial clefts)[1]....

Developmental midline abnormalities involving facial, optic, cranial, and cerebral structures are complex anomalies that require a multidisciplinary therapeutic approach. Radiologic evaluation requires identification of cerebral anatomy, orbital structures, facial bones, and the anterior fossa as well as the relationships of these structures to one another. We report an unusual combination of l...

Ectrodactyly-ectodermal dysplasia-clefting (EEC) syndrome is characterized by ectodermal dysplasia, ectrodactyly and facial clefting with multiple congenital anomalies such as urinary tract anomaly, lacrimal duct obstruction, and hearing loss. This syndrome is a rare disease transmitted by autosomal dominant inheritance with variable penetrance. Clinical expression is variable. In EEC syndrome ...

Holoprosencephaly is a common developmental disorder in humans characterised by incomplete brain hemisphere separation and midface anomalies. The etiology of holoprosencephaly is heterogeneous with environmental and genetic causes, but for a majority of holoprosencephaly cases the genes associated with the pathogenesis could not be identified so far. Here we report the generation of knockout mi...

In order to contribute to clinical delineation of midline facial defects with hypertelorism (MFDH) and to etiologic diagnosis of the isolated form, 31 patients with MFDH unaffected by known syndromic associations were evaluated. Group A included patients personally examined by the authors, while Group B included those previously evaluated by other geneticists. Among the 14 patients from Group A...

AIMS To document the optic disc abnormalities in patients with frontonasal dysplasia in association with basal encephalocele. METHODS Names and hospital numbers of patients with midline clefts were obtained from the ophthalmology and genetics database. Six patients were identified who had the following common findings: midline facial cleft with midline cleft lip and palate; hypertelorism; abs...

We propose a novel approach for detection of the facial midline from a frontal face image. Using midline as a guide reduces computational cost required for facial feature extraction (FFE) because the midline is capable of restricting multi-dimensional searching process into one-dimensional search. The proposed method detects the facial midline from an edge image as the symmetry axis using the g...