نتایج جستجو برای: mir 1
تعداد نتایج: 2789958 فیلتر نتایج به سال:
Objective(s):MicroRNAs (miRNAs) are a class of short RNAs that control the biological processes including cell proliferation, apoptosis and development. Aberrant expression of miRNAs was determined in the different stages of tumor development and metastasis. To study the effect of silibinin on miRNAs expression, we evaluated quantitative expression of miR-21 and miR-155 as two oncomiRs and seve...
Abstract Objective To investigate lncRNAs and their roles in regulating the pulmonary inflammatory response under dexamethasone (Dex) treatment. Methods IL-1? (10 ng/mL) LPS (1 ?g/mL) was used to construct cell models with A549 cells; performed better against LPS. Different concentrations of Dex were attenuate inflammation induced by IL-1?, its effect assessed via RT-PCR detect cytokine-related...
Background MicroRNAs (miRNAs) are non-coding RNA molecules (19-24 nucleotides) that play a major role in a wide range of biological processes through post-transcriptional regulation of gene expression. Differential expression of miRNAs has been reported in various infectious diseases such as HIV infection. The characterization of miRNA expression profiles, especially in mammalian biofluids, whi...
Objective(s): Various microRNAs (miRNAs) are expressed during development of mammalian cells, when they aid in modulating gene expression by mediating mRNA transcript cleavage and/or regulation of translation rate. miR-191 and miR-451 have been shown to be critical regulators of hematopoiesis and have important roles in the induction of erythroid fate decision. So, the aim of this study is inve...
abstract background and objective: various cellular factors affect the process of hiv activity. one of these cellular factors are structures known as microrn that are expected to be involved in controlling hiv replication and infectivity. the expression of one or a set of them may represent the patient's clinical conditions. in this study, the expression of mir-29a and mir-29b invo...
ملانوما یک تومور بدخیم از ملانوسیت است که مسئول 75% از مرگ ناشی از سرطان پوست می باشد. cd133 که به عنوان یک شاخص سلول های بنیادی سرطان در نظر گرفته می شود، در این نوع سرطان بیان می شود. همچنین به نظر می رسد این شاخص مسئول تهاجم و متاساز باشد. مطالعات نشان داده اند که پدیده ی گذر از مرحله ی اپیتلیالی به مزانشیمی (emt) نقش اصلی در فرآیند تهاجم و متاستاز دارد. هدف این مطالعه، جداسازی و بررسی سلول ...
Abstract Background and aim Malignant involvement of the pericardium is seen in 1 to 20 percent autopsies patients with cancer. The most common metastatic tumor involving lung cancer [1]. We aimed distinguish origin pericardial fluid effusion (i.e. pericarditis vs cancer) based on miRNAs expression peripheral blood plasma. Method 8 hospitalized for collection neoplastic aetiology (lung cancer)....
Introdution: In the present study, Lipofactamine 2000 was used as a cationic liposome for miR-101 transfection in order to investigate its cytotoxicity and its effect on the expression of ubiquitin ligase HECTH9 in acute myeloid leukemia cells (AML). Methods: MiR- 101 was transferred to KG-1 cells (myeloid cells) and HBMF-SPH (healthy bone marrow cells) using lipofectamine 2000 as a nano carri...
هدف: تمایز سلولهای بنیادی قلب با کمک میکروrnaها، دریچه جدیدی را برای ترمیم انفارکتوس قلبی گشوده است.mir-1-2/133a-1 و mir-206/133b دو خوشه مجزا از خانواده میکروrnaها هستند که به ترتیب در ماهیچههای قلبی و اسکلتی بیان میشود. چون mir-133b و mir-133a تنها در یک نوکلئوتید اختلاف دارند، احتمالاً مسیرها وmrna های یکسانی را مورد هدف قرار میدهند. هدف تحقیق حاضر، بررسی بیان احتمالی mir-133b در سلوله...
epilepsy is the third most common chronic brain disorder which is characterized by an enduring predisposition to generate seizures. mesial temporal lobe epilepsy (mtle) is the most common type of refractory epilepsy. increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of mtle. hundreds of micro-rnas have been found to be abnormally expressed in epilept...
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