Background: Atrial fibrillation (AF) is the most common complication in patients undergoing cardiac surgery. However, pathogenesis of postoperative AF (POAF) elusive, and research related to this topic sparse. Our study aimed identify key gene modules genes conduct a circular RNA (circRNA)-microRNA (miRNA)-messenger (mRNA) regulatory network analysis POAF on basis bioinformatic analysis.

AIM To identify the miRNA-mRNA regulatory network in hepatitis B virus X (HBx)-expressing hepatic cells. METHODS A stable HBx-expressing human liver cell line L02 was established. The mRNA and miRNA expression profiles of L02/HBx and L02/pcDNA liver cells were identified by RNA-sequencing analysis. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis was performed to investigat...

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a progressive, irreversible chronic inflammatory disorder typified by increased recruitment of monocytes, lymphocytes and neutrophils. Because of this, as well as the convenience of peripheral blood nuclear cells (PBMCs) assessments, miRNA profiling of PBMCs has drawn increasing attention in recent years for various disease. Therefore, ...

MicroRNAs (miRNAs) are small, noncoding regulatory molecules. They are involved in many essential biological processes and act by suppressing gene expression. The present work reports an integrative analysis of miRNA-mRNA and miRNA-miRNA interactions and their regulatory patterns using high-throughput miRNA and mRNA datasets. Aberrantly expressed miRNA and mRNA profiles were obtained based on f...

Circular RNAs (circRNAs) play key roles in several biological processes animals and their regulatory mechanism body color formation or pigmentation fish remains unclear. Here, circRNAs from black red individuals of Plectropomus leopardus were identified to clarify the competing endogenous RNA (ceRNA) network (circRNA-microRNA (miRNA)-messenger (mRNA)) formation. We detected a total 1,424 novel ...

MicroRNAs are small non-coding RNAs that can regulate expressions of their target genes at the post-transcriptional level. In this study, we propose a tri-component strategy that combines the conservation of microRNAs, homology of mRNA coding regions, and conserved microRNA binding sites in the 3' untranslated regions to discover conserved microRNA-mRNA interactions. To validate the performance...

Aim. To demonstrate the regulatory role of miRNA in colorectal carcinoma (CRC) and reveal the transcript markers that may be associated with CRC clinical outcomes. Method. Herein, we analyzed both mRNA and miRNA gene expression profiles of 255 CRC tumor samples from The Cancer Genome Atlas project to reveal the regulatory association between miRNA and mRNA. Also, the potential role of gene coex...