Background: Liver-expressed antimicrobial peptide-2 (LEAP-2) is an important component of innate immune system in teleosts. In order to understand isoform-specific involvement and regulation of LEAP-2 genes in mud loach (Misgurnus mizolepis, Cypriniformes), a commercially important food fish, this study was aimed to characterize gene structure and expression characteristics of two paralog LEAP-...

A disease outbreak occurred in June 2012 among mud loach cultured on pond farms in Jangseong-gun, Jeollanam-do, Korea. Mortality rates reached up to 1.2% in the farm per day. Typical clinical signs were bleeding ulcer at the middle portion of head and haemorrhagic erosion of the operculum. Based on biochemical characteristics, the causative bacterium isolated from diseased fish was identified a...