The stability of simple repetitive DNA sequences (microsatellites) is a sensitive indicator of the ability of a cell to repair DNA mismatches. In a genetic screen for yeast mutants with elevated microsatellite instability, we identified strains containing point mutations in the yeast mismatch repair genes, MSH2, MSH3, MLH1, and PMS1. Some of these mutations conferred phenotypes significantly di...

Asset-liability mismatch in balance sheet of banks shows serious challenges in banks because of the traditional methods of recording assets and liabilities at book value in Iran. The Central Bank of the country motivated and advised banks to take concrete steps in minimizing the mismatch in the asset-liability composition. This paper attempts to suggest a micro funded framework that can evaluat...

the most important factor in donor-recipient matching for hematopoietic stem cell transplantation is their hla typing. for many patients, we can not find a full-matched donor. in high risk patients, one locus  mismatched related donors are suitable alternatives. (1, 2) since the matching of patients and their siblings usually is based on low resolution hla typing, the matching of one locus mism...

BACKGROUND AND PURPOSE In acute stroke with proximal artery occlusion, FLAIR vascular hyperintensities observed beyond the boundaries of the cortical lesion on DWI (newly defined "FLAIR vascular hyperintensity-DWI mismatch") may be a marker of tissue at risk of infarction. Our aim was to compare the occurrence of FLAIR vascular hyperintensity-DWI mismatch relative to that of perfusion-weighted ...

The objective of this letter is to analyze the effects of frequency mismatch for an adaptive algorithm that becomes the Filtered-X LMS algorithm when the reference signals are purely sinusoidal. The Filtered-X LMS algorithm is often used for active control of acoustic noise. For the case of sinusoidal noise sources, if there is a deviation between the frequency used in the adaptive algorithm an...

Metamer mismatching (the phenomenon that two objects matching in color under one illuminant may not match under a different illuminant) potentially has important consequences for color perception. Logvinenko et al. [PLoS ONE10, e0135029 (2015)] show that in theory the extent of metamer mismatching can be very significant. This paper examines metamer mismatching in practice by computing the volu...

background: meiotic genes are very important candidates for genes contributing to female and male infertility. mammalian mutl homologues have dual roles in dna mismatch repair (mmr) after replication errors and meiotic reciprocal recombination. the mutl homologs, mlh1 and mlh3 , are crucial for meiotic reciprocal recombination and human fertility. in this study the functional polymorphisms of m...

I argue that research on organizational configurations has been limited by a mismatch between theory and methods and introduce set-theoretic methods as a viable alternative for overcoming this mismatch. I demonstrate the value of such methods for studying organizational configurations and discuss their applicability for examining equifinality and limited diversity among configurations, as well ...

background: hereditary non-polyposis colorectal cancer (hnpcc) is a common hereditary cancer predisposing syndrome has molecular and clinicopathological features still have remained ambiguous within iranian populations. we discuss in this article some molecular and clinicopathological features of the condition. methods: the study was a descriptive retrospective and designed on 1659 colorectal c...