Understanding a complex biological system, such as the mitochondrion, requires the identification of the complete repertoire of proteins targeted to the organelle, the characterization of these, and finally, the elucidation of the functional and physical interactions that occur within the mitochondrion. In the last decade, significant developments have contributed to increase our understanding ...

FIGURE 4 Section reveals three mitochondrial complexes (arrows) . In one mitochondrion a divalent cation granule (G) can also be seen . X 15,000 . FIGURE 3 Longitudinal section of mitochondrion . The complex appears to be arranged in a helical manner . X 35,000 . FIGURE 4 Cross section of mitochondrion showing complex . X 35,000 . FIGURES 5-8 Sections of mitochondria from cells treated for 8 h ...

In studies on the distribution of lead in rats given drinking water containing lead acetate at concentrations: 0, 100, 500, 1000 and 5000 ,ugPb/l for one year, no change was observed in the organ distribution of lead, or in the subcellular distribution of lead in the organelles in the heart. The mitochondrial enzyme, ferrochelatase, was significantly depressed in both the 500 and 1000 ptg/l gro...

The mitochondrion of Plasmodium species is a validated drug target. However, very little is known about the functions of this organelle. In this review, we utilize data available from the Plasmodium falciparum genome sequencing project to piece together putative metabolic pathways that occur in the parasite, comparing this with the existing biochemical and cell biological knowledge. The Plasmod...

The fine structure of mitochondria and mitochondrial nucleoids in exponentially growing Physarum polycephalum was studied at various periods throughout the mitochondrial division cycle by light and electron microscopy. The mitochondrial nucleoid elongates lingitudinally while the mitochondrion increases in size. When the nucleoid reaches a length of approximately 1.5 mum the mitochondrial membr...

Low-density lipoproteins (LDLs) reconstituted with a multifunctional mitochondrion-targeting photosensitizer are able to achieve fluorescence-feedback photodynamic therapy of LDL receptor-overexpressing cancer cells.