To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evaluated in vitro and in vivo rats. Morin-loaded mixed micelle formulation with a morin-PluronicF127-Tween80 ratio of 1 : 10 : 0.02 (w/w/w) was prepared by a thin-film hydration method. The solubility, ...

A dual mixed finite element method, for quasi–Newtonian fluid flow obeying to the power law, is constructed and analyzed in [8]. This mixed formulation possesses local (i.e., at element level) conservation properties (conservation of the momentum and the mass) as in the finite volume methods. We propose here an a posteriori error analysis for this mixed formulation.

In this paper we present a new mixed variational formulation for the problem of linear elastostatics. Our formulation is very similar to the classical HellingerReissner formulation, but appears superior for finite element discretization. To make plain the relation between the Hellinger-Reissner formulation and the present one, we consider first an elastic body occupying a region g? in Euclidean...

A wide range of problems can be modeled as Mixed Integer Linear Programming (MILP) problems using standard formulation techniques. However, in some cases the resulting MILP can be either too weak or to large to be effectively solved by state of the art solvers. In this survey we review advanced MILP formulation techniques that result in stronger and/or smaller formulations for a wide class of p...

We develop the theory of degenerate and nonlinear evolution systems in mixed formulation. It will be shown that many of the well-known results for the stationary problem extend to the nonlinear case and that the dynamics of a degenerate Cauchy problem is governed by a nonlinear semigroup. The results are illustrated by a Darcy–Stokes coupled system with multiple nonlinearities.

The Brinkman model is a unified law governing the flow of a viscous fluid in cavity (Stokes equations) and in porous media (Darcy equations). In this work, we explore a novel mixed formulation of the Brinkman problem. Introducing the flow’s vorticity as additional unknown, this formulation allows for a uniformly stable and conforming discretization by standard finite elements (Nédélec, Raviart-...

Combined attracticide formulations targeting Oriental fruit moth, Grapholita molesta (Busck), and codling moth, Cydia pomonella (L.), were tested in a field trapping experiment. Capture of male codling moths in traps baited with the combined formulation was reduced compared with traps baited with the codling moth formulation alone, whereas capture of male Oriental fruit moth was increased compa...

The recently proposed expanded mixed formulation for numerical solution of second order elliptic problems is here extended to fourth order elliptic problems. This expanded formulation for the diierential problems under consideration diiers from the classical formulation in that three variables are treated, i.e., the displacement and the stress and moment tensors. It works for the case where the...

We develop a new mixed formulation for the numencal solution of second-order elliptic problems This new formulation expands the standard mixed formulation in the sense that three variables are exphcitly treated the scalar unknown, its gradient, and its flux (the coefficient times the gradient) Based on this formulation, mixed finite element approximations of the second-order elliptic problems a...