This work presents a review of the applications of mixed-integer nonlinear programming (MINLP) in process systems engineering (PSE). A review on the main deterministic MINLP solution methods is presented, including an overview of the main MINLP solvers. Generalized disjunctive programming (GDP) is an alternative higher-level representation of MINLP problems. This work reviews some methods for s...

In this study, a flexible optimization approach is introduced to design an optimal biocompatible solvent for an extractive fermentation process with cell-recycling. The optimal process/solvent design problem is formulated as a mixed-integer nonlinear programming model in which performance requirements of the compounds are reflected in the objectives and the constraints. A flexible or fuzzy opti...

We consider a production planning problem where the production process creates a mixture of desirable products and undesirable byproducts. In this production process, at any point in time the fraction of the mixture that is an undesirable byproduct increases monotonically as a function of the cumulative mixture production up to that time. The mathematical formulation of this continuous-time pro...

This contribution describes the development of various strategies for the dynamic optimization of a batch reactor in order to obtain a robust model, suitable for nonlinear (NLP) or mixed-integer nonlinear programming (MINLP) problems. Different Orthogonal Collocation on Finite Element (OCFE) schemes and various formulations of the MINLP model have been studied to increase its robustness. It has...

Optimizing scheduling is an effective way to improve the profit of refineries; it usually requires accurate models to describe the complex and nonlinear refining processes. However, conventional nonlinear models will result in a complex mixed integer nonlinear programming (MINLP) problem for scheduling. This paper presents a piecewise linear (PWL) modeling approach, which can describe global no...

Primal heuristics are an important component of state-of-the-art codes for mixed integer nonlinear programming (MINLP). In this article we give a compact overview of primal heuristics for MINLP that have been suggested in the literature of recent years. We sketch the fundamental concepts of different classes of heuristics and discuss specific implementations. A brief computational experiment sh...

In the context of a variation of the standard UFL (Uncapacitated Facility Location) problem, but with an objective function that is a separable convex quadratic function of the transportation costs, we present some techniques for improving relaxations of MINLP formulations. We use a disaggregation principal and a strategy of developing model-specific valid inequalities (some nonlinear), which e...

Mixed Integer Nonlinear Programming (MINLP) problems present two main challenges: the integrality of a subset of variables and nonconvex (nonlinear) objective function and constraints. Many exact solvers for MINLP are branch-and-bound algorithms that compute a lower bound on the optimal solution using a linear programming relaxation of the original problem. In order to solve these problems to o...

This paper presents an efficient optimization algorithm for mixed integer nonlinear programming (MINLP) problem resulting from multiple partially linearized (MPL) model based control of nonlinear hybrid dynamical system (NHDS). The algorithm uses structural information of the canonical MPL framework and derives comparatively easier quadratic programming (QP) primal problem as well as an MILP ma...

this paper presents a formulation of unit commitment for thermal units integrated with wind and solar energy systems and electrical vehicles with emphasizing on mixed integer nonlinear programming (minlp). the renewable energy resources are included in this model due to their low electricity cost and positive effect on environment. as well as, coordinated charging strategy of electrical vehicle...