Streptococcus pseudopneumoniae (SPpn) is a relatively new species closely related to S. pneumoniae (SPn) and mitis (SM) belonging the Mitis group of genus (MGS). Although genes encoding various pneumococcal virulence factors have been observed in SPpn genome, pathogenicity against human, including roles factor candidates, still unclear. The present study focused on characterized candidate previ...

Monte Carlo (MC) algorithms are recognized as the most accurate methodology for patient dose assessment. For intensity-modulated radiation therapy (IMRT) delivered with dynamic multileaf collimators (DMLCs), accurate dose calculation, even with MC, is challenging. Accurate IMRT MC dose calculations require inclusion of the moving MLC in the MC simulation. Due to its complex geometry, full trans...

Intensity-modulated radiation therapy (IMRT) plans for the treatment of large and complex volumes may contain a relatively large contribution from multileaf collimator (MLC) transmission. In such cases, comprehensive characterization of direct and scatter MLC transmission is important. We designed a set of tests (open beam, closed static MLC, and dynamic MLC gap) to determine dosimetric MLC pro...

Myosin light chain (MLC) phosphorylation plays important roles in various cellular functions such as cellular morphogenesis, motility, and smooth muscle contraction. MLC phosphorylation is determined by the balance between activities of Rho-associated kinase (Rho-kinase) and myosin phosphatase. An impaired balance between Rho-kinase and myosin phosphatase activities induces the abnormal sustain...

The purpose of this study is to simulate random and systematic RapidArc delivery errors for external beam prostate radiotherapy plans in order to determine the dose sensitivity for each error type. Ten prostate plans were created with a single 360° arc. The DICOM files for these treatment plans were then imported into an in-house computer program that introduced delivery errors. Random and syst...

The global regulator Mlc is a repressor of several genes and operons that are involved in sugar uptake and metabolism. A Salmonella enterica serovar Typhimurium mlc mutant showed reduced levels of invasion and cytotoxicity compared to the wild-type, and exhibited reduced expression levels of hilD, hilA and invF, which are regulatory genes in the Salmonella pathogenicity island 1 (SPI1). However...

WHEN it was observed that the majority of SD-identical unrelated individuals stimulated each other in the MLC test, it was postulated in agreement with earlier suggestions by others that MLC activation might be coded by a locus separate from the LA and Four loci." The existence of such a MLC locus is now generally accepted.^About 10% of the MLC tests between SD-identical unrelated persons are n...

We report the presence of Mlc in a thermophilic bacterium. Mlc is known as a global regulator of sugar metabolism in gram-negative enteric bacteria that is controlled by sequestration to a glucose-transporting EII(Glc) of the phosphotransferase system (PTS). Since thermophilic bacteria do not possess PTS, Mlc in Thermus thermophilus must be differently controlled. DNA sequence alignments betwee...

megalencephalic leukoencephalopathy with subcortical cysts (mlc) is an autosomal recessive disorder characterized by macrocephaly and a slowly progressive clinical course marked by ataxia, spasticity and mental decline. mlc is caused by mutations in the gene mlc1 which encodes a novel protein, mlc1. here we report 4 cases presenting with macrocephaly, spasticity, ataxia and abnormal cerebral wh...

introduction: this study compared apical dye penetration using lateral condensation technique (lc) and lc technique with a reciprocal handpiece (mechanical lateral condensation or mlc) as a new method. materials and methods: forty-eight human extracted straight canine teeth were used. after crown amputation, the teeth were randomly divided into four experimental groups of 10 teeth each and two ...