نتایج جستجو برای: mmps activity

تعداد نتایج: 1137292  

Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...

Many species belonging to the Scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. The aim of this study was to characterize the matrix metalloproteinases (MMPs) inhibitor compounds of the Scrophularia striata extract by bio-guide fractionation. The aerial parts of S. striata were...

Journal: :International Journal of Molecular Sciences 2021

Stroke is one of the leading causes death and disability worldwide. However, treatment options for ischemic stroke remain limited. Matrix-metalloproteinases (MMPs) contribute to brain damage during strokes by disrupting blood-brain barrier (BBB) causing edemas. Carnosine, an endogenous dipeptide, was found us others be protective against injury. In this study, we investigated whether carnosine ...

Journal: :Acta neurobiologiae experimentalis 2009
Luiza Wojcik Aleksandra Sawicka Santiago Rivera Teresa Zalewska

Accumulating evidence indicates that cerebral ischemia enhances neurogenesis in the adult brain. The mechanisms responsible for stem-cell development are poorly understood. Recent in vitro studies indicate the involvement of metalloproteinase (MMPs) in the regulation of proliferation and differentiation of neural progenitor cells. To elucidate if MMPs participate in neurogenesis-associated proc...

Journal: :Postepy higieny i medycyny doswiadczalnej 2012
Krzysztof Fink Janusz Boratyński

Extracellular matrix metalloproteinases (MMPs) are a family of endopeptydases which recquire a zinc ion at their active site, for proteolityc activity. There are six members of the MMP family: matrilysins, collagenases, stromelysins, gelatinases, membrane MMPs and other MMPs. Activity of MMPs is regulated at the level of gene transcription, mRNA stability, zymogene proteolitic activation, inhib...

Fatemeh Hajighasemi

Background: Leukemia is a malignant proliferative disorder of the hematopoietic cells. The important role of angiogenesis in leukemia has been reported by several studies. Matrix metalloproteinases (MMPs) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. Objective: The present study was conducted to evaluate the patterns of ...

Journal: :Molecules 2023

Matrix metalloproteinases (MMPs) are zinc-dependent that play important roles in a variety of diseases, including cancer, cardiovascular disease, diabetes, obesity, and brain diseases. Dietary polyphenols thought to have beneficial effects on these diseases characterized by inflammation. Clinical studies demonstrated MMPs most cases upregulated various inflammatory osteoarthritis, rheumatoid ar...

Journal: :iranian journal of pharmaceutical research 0
hamid reza monsef–esfahani department of pharmacognosy, faculty of pharmacy, tehran university of medical sciences, tehran, iran ahmad reza shahverdi department of pharmaceutical biotechnology and pharmaceutical research center, faculty of pharmacy, tehran university of medical sciences, tehran, iran mohammad reza khorramizadeh department of pathobiology, school of public health, tehran university of medical sciences, tehran, iran mohsen amini department of medicinal chemistry, faculty of pharmacy, tehran university of medical sciences, tehran, iran and drug design and development research center, tehran university of medical sciences, tehran, iran reza hajiaghaee department of pharmacognosy & pharmaceutics, institute of medicinal plants, acecr, karaj, iran

many species belonging to the scrophularia genus have been used since ancient times as folk remedies for many medical conditions such as scrofulas, scabies, tumors, eczema, psoriasis, inflammations. the aim of this study was to characterize the matrix metalloproteinases (mmps) inhibitor compounds of the scrophularia striata extract by bio-guide fractionation. the aerial parts of s. striata were...

Journal: :Turkish Journal of Biology 2023

Background/aim: Matrix metalloproteinases (MMPs) play an important role in the evaluation of many cancer types; however, detection usually presents a challenge. Further assays for better understanding fundamental roles MMPs pathophysiology are still needed. We aimed to use activatable probe scanning acoustic microscopy (SAM) evaluate acoustically if can aid visualization effects vitro MMP activ...

Journal: :Journal of Esthetic and Restorative Dentistry 2013

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