نتایج جستجو برای: mononuclear leukocytes
تعداد نتایج: 74561 فیلتر نتایج به سال:
ill sllhcutaneous diffusion chambers have demonstrated that certain mononuclear leukocytes ( lymphocytes and/or monocytes ) from the blood of huniaii adults, vlien so cultivated, have a “mesenchymal” capacity audi are capable of undergoing differentiation to macrophages and to collagen-producing fibroblasts) The cells possessing this capacity for differentiation are probably identical with thos...
BACKGROUND The extraction of RNA from leukocytes for reverse transcription-PCR (RT-PCR) is time-consuming and contributes to variation in analysis of the Philadelphia (Ph1) chromosome of chronic myelogenous leukemia (CML) by RT-PCR. To detect residual CML after bone marrow transplantation, mRNA from at least 10(5) leukocytes should be analyzed, but the RNase activity of the cells precludes simp...
RATIONALE Toll-like receptors 2 and 4 (TLR2, TLR4) enable cellular responses to bacterial lipoproteins, LPS, and endogenous mediators of cell damage. They have an established role in the activation of leukocytes, endothelial cells, and some smooth muscle cell types, but their roles in airway smooth muscle are uncertain. OBJECTIVES To determine the roles of TLRs in activation of airway smooth ...
Background There is growing evidence for a pathogenic role for cytokines in atherogenesis. The presence of certain cytokines has been documented in human atherosclerotic vessels. This study was designed to investigate cytokine production by mononuclear leukocytes from patients with ischemic heart disease. Methods and Results We measured kinetics of secretion of tumor necrosis factor-a (TNF-a) a...
BACKGROUND There is growing evidence for a pathogenic role for cytokines in atherogenesis. The presence of certain cytokines has been documented in human atherosclerotic vessels. This study was designed to investigate cytokine production by mononuclear leukocytes from patients with ischemic heart disease. METHODS AND RESULTS We measured kinetics of secretion of tumor necrosis factor-alpha (TN...
BACKGROUND Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure. However, the best female genital tract sampling technique is unclear. METHODS AND FINDINGS We enrolled women from four sites in Africa and the US to compare three genital leukocyte sampling me...
It is characteristic for virus infections that monocytes/macrophages and lymphocytes infiltrate infected tissue while neutrophils are absent. To understand the mechanisms selectively attracting mononuclear cells in viral diseases, we examined in an influenza A virus model the expression and regulation of chemokines as candidate molecules responsible for the immigration of leukocytes into inflam...
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