نتایج جستجو برای: morphogen gradients

تعداد نتایج: 39070  

Journal: :Proceedings of the National Academy of Sciences 2011

Journal: :Physical Review Letters 2005

Journal: :Cell 2012
Michal Haskel-Ittah Danny Ben-Zvi Merav Branski-Arieli Eyal D. Schejter Ben-Zion Shilo Naama Barkai

Morphogen gradients pattern tissues and organs during development. When morphogen production is spatially restricted, diffusion and degradation are sufficient to generate sharp concentration gradients. It is less clear how sharp gradients can arise within the source of a broadly expressed morphogen. A recent solution relies on localized production of an inhibitor outside the domain of morphogen...

Journal: :Current opinion in genetics & development 2011
Danny Ben-Zvi Ben-Zion Shilo Naama Barkai

Individuals of the same or closely related species can vary substantially in size. Still, the proportions within and between tissues are precisely kept. This adaptation of pattern with size termed scaling, is receiving a growing attention. We review experimental evidence for scaling, and describe theoretical models for mechanisms that scale morphogen gradients. We particularly note the Expansio...

Journal: :Discrete and continuous dynamical systems. Series B 2013
Jinzhi Lei Dongyong Wang You Song Qing Nie Frederic Y M Wan

Robust multiple-fate morphogen gradients are essential for embryo development. Here, we analyze mathematically a model of morphogen gradient (such as Dpp in Drosophila wing imaginal disc) formation in the presence of non-receptors with both diffusion of free morphogens and the movement of morphogens bound to non-receptors. Under the assumption of rapid degradation of unbound morphogen, we intro...

Journal: :Cell 2001
Aurelio A. Teleman Maura Strigini Stephen M. Cohen

Shh activity and at different distances from the source. The proper functioning of tissues and organs requires These observations provide unequivocal evidence that that each cell differentiate appropriately for its position. Shh acts directly on distant cells and therefore that Shh In many cases, the positional information that instructs forms a morphogen gradient in the developing neural cells...

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