The time courses for production of fungal biomass, lipid, phenolic and arachidonic acid (ARA) as well as expression of the genes involved in biosynthesis of ARA and lipid were examined in Mortierella alpina CBS 754.68. A significant increase in the arachidonic acid content in lipids that coincided with reduced levels of lipid was obtained. Reduced gene expression occurred presumably due to the ...

BACKGROUND Arachidonic acid (ARA, C20:4, n-6), which belongs to the omega-6 series of polyunsaturated fatty acids and has a variety of biological activities, is commercially produced in Mortierella alpina. Dissolved oxygen or oxygen utilization efficiency is a critical factor for Mortierella alpina growth and arachidonic acid production in large-scale fermentation. Overexpression of the Vitreos...

Mortierella alpina (M. alpina) is well known for arachidonic acid (ARA) production. However, low efficiency and unstableness are long existed problems for industrial production of ARA by M. alpina due to the lack of online regulations. The aim of the present work is to develop an online-regulation strategy for efficient and stable ARA production in industry. The strategy was developed in 50 L f...

Tetrahydroquinoline (1), prepared by a traditional synthetic method, the imino Diels-Alder reaction, was biotransformed by Mortierella isabelina to afford a new compound, 2, characterized by spectroscopic methods.

Recent studies show that Mortierella elongata can perform plant-growth promotion across different types of crops, including bahiagrass, corn, tomato, squash, and watermelon. Compared to the well-known species have plant-growth-promotion abilities (e.g., mycorrhizal fungi, Trichoderma), growers, agents, stakeholders are not familiar with "Mortierella" despite important role these fungal taxa pla...

The esterase profiles of 9 strains of Mortierella ramanniana grown on glucose and olive-oil media were determined by starch-gel electrophoresis. The enzymes produced on the oil medium were in most instances produced also on the glucose medium, but on the latter some additional esterase components were produced. The esterase patterns of the different strains varied widely; only one esterase was ...

Three β-cyclocitral-derived halolactones, which exhibit antifeedant activity towards storage product pests, were subjected to microbial transformation processes. Among the thirty tested strains of filamentous fungi and yeast, the most effective biocatalysts were Absidia cylindrospora AM336, Mortierella isabellina AM212 and Mortierella vinaceae AM149. As a result of regio- and enantioselective h...

BACKGROUND Fungal morphology and aeration play a significant role in the growth process of Mortierella alpina. The production of microbial oil rich in arachidonic acid (ARA) in M. alpina was enhanced by using a multi-stage fermentation strategy which combined fed-batch culture with precise control of aeration and agitation rates at proper times. RESULTS The fermentation period was divided int...

We have isolated a novel gene (GLELO) from Mortierella alpina and its homologue (CEELO1) from Caenorhabditis elegans and demonstrate the involvement of their encoded proteins in the elongation of C(18) polyunsaturated fatty acids.

Canopy disturbances such as windthrow events have obvious impacts on forest structure and composition aboveground, but changes in soil microbial communities and the consequences of these changes are less understood.We characterized the densities of a soil-borne pathogenic oomycete (Pythium) and a common saprotrophic zygomycete (Mortierella) in nine pairs of forest gaps created by windthrows and...