Patients with mutations of the THRA gene exhibit classical features of hypothyroidism, including erythroid disorders. We previously created a mutant mouse expressing a mutated TRα1 (denoted as PV; Thra1PV/+ mouse) that faithfully reproduces the classical hypothyroidism seen in patients. Using Thra1PV/+ mice, we explored how the TRα1PV mutant acted to cause abnormalities in erythropoiesis. Thra1...

With respect to radiation damage to humans, it is important to seek possible radioprotectants to modify the normal response of biological systems to radiation-induced toxicity or lethality. For this reasons, the search for less-toxic radiation radioprotectants has spurred interest in the development of different compounds. The radioprotective effects of citrus extract were investigated by using...

With respect to radiation damage to humans, it is important to seek possible radioprotectants to modify the normal response of biological systems to radiation-induced toxicity or lethality. For this reasons, the search for less-toxic radiation radioprotectants has spurred interest in the development of different compounds. The radioprotective effects of citrus extract were investigated by using...

The cytogenetic effect of the insecticide methamidophos (0,S-dimethylphosphoroamidothiolate) was studied in mouse bone marrow and mouse spleen cells in culture. In vivo the ability of methamidophos to induce micronuclei and sisterchromatid exchange in mouse bone marrow was investigated. In vitro mouse spleen cells in culture were used to assess the ability of the insecticide to induce chromosom...

in this study granulocyte-macrophage colony stimulating factor (csf) was prepared from rabbit and guinea pig lung tissues. the biological activity of these csfs was measured on semisolid agar culture and compared with those of mouse and rat. weight of animals, incubation time and cross-reactivity of csfs with different bone marrow sources were also investigated. the results showed that both rab...

background: in recent years, the widespread use of microwave producing instruments specially mobile phones; result in growing concern regarding the possible effects associated with these waves on human health. in the present study investigated the genotoxic effects of mobile phone radiation in adult mice (balb/c) and their embryos. methods: in this experimental research pregnant mice were irrad...

Enhanced cellular DNA repair efficiency and suppression of genomic instability have been proposed as mechanisms underlying radio-adaptive responses following low-dose radiation exposures. We previously showed that low-dose γ irradiation does not generate radio-adaptation by lowering radiation-induced cytogenetic damage in mouse spleen. Since radiation may exert tissue-specific effects, we exten...

background: interactions of free radicals from ionizing radiation with dna can induce dna damage and lead to mutagenesis and carsinogenesis. with respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation. in the present study, the effects of arbutin were investigated by using the micronucleus test for anti-clastogenic activity, to ca...

Immunocytochemical staining of tissues with the mouse macrophage-specific monoclonal antibody, F4/80, has shown that large numbers of stromal macrophages are present in adult and foetal haematopoietic tissues. Macrophage plasma membrane processes are seen to establish extensive associations with myeloid and erythroid cells in adult bone marrow and with developing erythroblasts in foetal liver, ...