The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...

PURPOSE To evaluate the safety and efficacy of 0.05 mL intracameral injection of moxifloxacin in patients who underwent phacoemulsification and intraocular lens (IOL) implant. METHODS Retrospective study comprising patients who underwent phacoemulsification and IOL implant between January 2009 and December 2013. Patients were divided into two groups. Group A followed standard endophthalmitis ...

A RP-HPLC method for the separation and determination of impurities of moxifloxacin, in its pharmaceutical forms as well as moxifloxacin degradation products, was developed with the aid of DryLab software and chemometric (response surface) approach. The separation of four synthesis-related impurities was achieved on a Waters C(18) XTerra column using a mobile phase of (water+triethylamine (2%, ...

In this study, nanofibers with different ratios of poly(vinyl alcohol) and chitosan incorporated moxifloxacin hydrochloride (MH/PVA/CS) were fabricated through the blending electrospinning, morphological features tested using scanning electron microscopy (SEM). Further characterization new nanofiber was accomplished by Thermogravimetric analysis (TG), X-ray diffraction (XRD) Fourier-transform i...

The objective of the present investigation was to prepare and evaluate ocular inserts of moxifloxacin. An ocular insert was made from an aqueous dispersion of moxifloxacin, sodium alginate, polyvinyl alcohol, and dibutyl phthalate by the film casting method. The ocular insert (5.5 mm diameter) was cross-linked by CaCl2 and was coated with Eudragit S-100, RL-100, RS-100, E-100 or L-100. The in v...

In recent years, the use of ion-selective membranes in sensing and assessment environmental contaminants has become a critical goal. Using sodium tetraphenylborate (TPB) phosphotungstic acid (PTA) as ion-pairing agents, two sensitive selective sensors were manufactured to evaluate electrochemical response moxifloxacin hydrochloride (MOX). The optimal behavior was attained by fine-tuning all ass...

PURPOSE To review current and past practices of intracameral antibiotic administration for infection prophylaxis in cataract surgery; to review the benefits and liabilities of available prophylactic drugs, dosage determination, and administration protocols; and to devise an optimum dose and administration protocol for intracameral moxifloxacin. SETTING Humber River Hospital and the University...