To investigate the mechanism of azalomycin F5a against methicillin-resistant Staphylococcus aureus (MRSA), the conductivity of MRSA suspension and the adenylate kinase activity of MRSA culture were determined with the intervention of azalomycin F5a, which were significantly increased compared to those of blank controls. This inferred that azalomycin F5a could lead to the leakage of cellular sub...

The emergence of multidrug-resistant microorganisms represents a global challenge owing to the lack new effective antimicrobial agents. Essential oils could be an alternative antibiotics because their anti-inflammatory, antiviral, antibacterial, and antibiofilm activities. Therefore, this study aimed investigate antibacterial activity essential as antibiotics. In present study, we cultured meth...

OBJECTIVES Glycopeptides have historically been the drugs of choice for the treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA). However, the continued selective pressure has led to the emergence of non-susceptible strains including heterogeneously vancomycin-intermediate S. aureus (hVISA). Infections with hVISA have been associated with poor outcomes including ...

The prevalence of methicillin-resistant Staphyloccoccus aureus (MRSA) strains has presented a new challenge in antimicrobial medication. Linezolid is a new drug with potent activity on Gram-positive pathogens such as MRSA. The aim of the study was to investigate the in vitro activity of linezolid alone and in combination with imipenem, vancomycin or rifampicin to determine the most active thera...

Objective(s): The novel healing choices for handling of infections due to multidrug resistant Staphylococcus aureus are reguired. HAMLET has been reported to be able to sensitize bacterial pathogens to traditional antimicrobial agents. The aim was to assess wound healing activity of methicillin in presence of HAMLET in methicillin resistant S. aureus (MRSA) infected wounds. Materials and Method...

The antimicrobial killing activity toward methicillin-resistant Staphylococcus aureus (MRSA) has been a serious emerging global issue. In a continuing search for compounds with antibacterial activity against several microorganisms including S. aureus and MRSA, an n-hexane extract of Magnolia officinalis was found to contain magnolol. This compound exhibited potent activity against S. aureus, st...

conclusions the overall results indicated that bacteriophages isolated from sewage exhibited excellent lytic activity against mrsa strains. in conclusion, bacteriophages can be further characterized and appear to be a promising candidate for phage therapy against mrsa in the future. results the phages exhibited good lytic activity against mrsa when tested in-vitro, and the highest activity was ...

conclusions the streptomyces sp. suk 25 culturing was optimized using thronton media, at ph 7 and aeration of 140 rpm. further isolation and identification of bioactive compounds will develop anti-mrsa therapeutics. materials and methods disc diffusion and minimum inhibitory concentration (mic) assay were used to determine the antibacterial activity of streptomyces sp. isolates. optimization of...

Methicillin-resistant Staphylococcus aureus (MRSA), along with other antibiotic resistant bacteria, has become a significant social and clinical problem. There is thus an urgent need to develop naturally bioactive compounds as alternatives to the few antibiotics that remain effective. Here we assessed the in vitro activities of bee venom (BV), alone or in combination with ampicillin, penicillin...

Staphylococcus aureus is a major human pathogen, implicated in both community and hospital acquired infections. The therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult because of multidrug resistance and strong biofilmforming properties. Schiff bases have attracted attention as promising antibacterial agents. In this study, we investigated the in...