The expression of melanotransferrin (MTf), a membrane-bound glycoprotein highly expressed in melanomas, is correlated with tumor vascularization and progression, suggesting a proinvasive function associated with MTf in malignant tumors. To test this hypothesis, we silenced MTf in human melanoma SK-MEL-28 cells using small interfering RNA (siRNA) and examined the plasmin activity and invasivenes...

Metal activation of metallothionein gene transcription depends mainly on the presence of regulatory DNA sequences termed metal-regulatory elements (MREs) and involves MRE-binding transcription factor-1 (MTF-1) interacting with the MREs in a Zn(2+)-dependent manner. We previously identified and characterized a nuclear protein, termed metal element protein-1 (MEP-1), specifically binding with hig...

Although turbulence is usually considered to be the primary cause of image blur, simultaneous and independent measurements of overall atmospheric modulation transfer function (MTF) and turbulence MTF over fairly long horizontal paths at 15-m average elevation indicate that, even at midday, aerosol MTF deriving from forward scatter is usually more dominant than turbulence MTF. Three different ex...

Defocusing effects in modulation transfer function (MTF) measurement of charge coupled device (CCD) cameras is the main focus of current paper. We introduce measuring Point-spread function (PSF) in order to calculate the MTF and further more we will study the shape of MTF and its cut-off frequency by adjusting the lens focusing in different locations. A collimated white light LED by broadband s...

A new measurement method is proposed to separately measure the effect of ink spread and optical dot gain on the MTF (modulation transfer function) of printed images from an ink jet printer. The transmittance and reflectance of the same printed images are captured with two different illuminations: one on the printing surface (for measuring reflectance) and the other through the paper base surfac...

The modulation transfer function (MTF) is the technical description of spatial resolution for most imaging systems. the MTF describes how well an imaging system processes signal [1,4]. There are several methods for calculation of MTF that can be categorized in theoretical and experimental methods. In this study, in order to compare the performance of five different commercial CT scanner, an exp...

Mitochondrial ferritin (MtF) has been identified as a novel ferritin encoded by an intron-lacking gene with specific mitochondrial localization located on chromosome 5q23.1. MtF has been associated with neurodegenerative disorders such as Friedreich ataxia and restless leg syndrome. However, little information is available about MtF in Alzheimer's disease (AD). In this study, therefore, we inve...

Metal-response element (MRE)-binding transcription factor-1 (MTF-1) is a zinc-regulated transcriptional activator of metallothionein (MT) genes in mammalian cells. The MRE-binding domain of MTF-1 (MTF-zf) has six canonical Cys(2)-His(2) zinc finger domains that are distinguished on the basis of their apparent affinities for zinc and their specific roles in MRE-binding. In this paper, pulsed alk...

Metal ion homeostasis and heavy metal detoxification systems are regulated by certain genes associated with metal ion transport. Metallothionein (MT) and metal response element binding transcription factor 1 (MTF‑1) are important regulatory proteins involved in the mediation of intracellular metal ion balance. Differences in the zinc‑binding affinities of the zinc fingers of MTF‑1 and the α‑ an...

Male to female gender identity disorder (MTF/GID) is a rare condition. Such patients tend complain that their speaking fundamental frequency (SFF) does not fit because it too low. Type 4 thyroplasty (TP4) conversely increases the pitch of SFF as tension vocal fold tightened causing become high-pitched. While life-threatening for with MTF/GID, can cause substantial worry and stress. TP4 therefor...