Prostate cancer (PC) is one of the prevalent tumors in men causing higher mortality. Luteoloside has been discovered for suppressive role into progression some cancers. However, Luteoloside’s regulatory functions regarding PC are not well understood. This study thus designed to investigate impact on progression. In this work, it was demonstrated that cell proliferation gradually inhibited with ...

Deptor is a protein that interacts with mTOR and belongs to the mTORC1 mTORC2 complexes. capable of inhibiting kinase activity mTOR. It well known pathway involved in various signaling pathways are biological processes such as cell growth, apoptosis, autophagy, ER stress response. Therefore, Deptor, being natural inhibitor mTOR, has become very important its study. Because this, it research rol...

Abstract Background Receptive endometrium is a restraining factor in the establishment of pregnancy several estrogen-dependent gynecological disorders including uterine leiomyomas. Recently, data are beginning to accrue suggesting negative impact non-cavity distorting intramural fibroids on molecular mediators endometrial receptivity. The potential importance mammalian target rapamycin (mTOR) s...

The effects of insulin on the mammalian target of rapamycin, mTOR, were investigated in 3T3-L1 adipocytes. mTOR protein kinase activity was measured in immune complex assays with recombinant PHAS-I as substrate. Insulin-stimulated kinase activity was clearly observed when immunoprecipitations were conducted with the mTOR antibody, mTAb2. Insulin also increased by severalfold the 32P content of ...

Purpose: To determine the role and mechanisms of Krüppel-like transcription factor 8 (KLF8) in acute myeloid leukemia (AML).Methods: The transcriptional translational levels KLF8 AML cell lines were determined by quantitative real time-polymerase chain reaction (qRT-PCR) western blotting. Two RNAs targeting transfected into KG-1 HL-60 cells. growth apoptosis cells using CCK-8, 5-ethynyl-2-deoxy...

triple negative breast cancers (tnbcs) are associated with aggressive course, higher rates of visceral and central nervous system metastases and lower survival rate than hormone receptor positive. once metastasis has occurred, a median survival was approximately one year. currently, chemotherapy in tnbc is similar to other her2- negative breast cancers but in the near future, it will revolution...

The mammalian target of rapamycin (mTOR) plays key roles in cellular metabolism and hypertrophic-hyperplasic growth, and it acts as a central regulator of protein synthesis and ribosome biogenesis at the transcriptional and translational levels by sensing and integrating signals from mitogens and nutrients. Hormonal and stress factors can affect the mTOR-signaling pathway via their receptors an...

The PI3K/mTOR/AKT pathway might represent an intriguing option for treatment of penile cancer (PeCa). We aimed to assess whether members this serve as biomarkers and targets systemic therapy. Tissue primary from treatment-naïve PeCa patients was used tissue microarray analysis. Immunohistochemical staining performed with antibodies against AKT, pAKT, mTOR, pmTOR, pS6, pPRAS, p4EBP1, S6K1 pp70S6...

This experiment aims to investigate the effects of partial replacement fish meal (FM) by soybean (SBM) and/or fermented (FSBM) on growth, serum biochemistry, digestion, antioxidation, immunity, and mTOR signaling pathway juvenile coho salmon (Oncorhynchus kisutch). Four iso-nitrogen iso-lipid diets were designed fed four groups (152.25 ± 2.96 g) in triplicate for 10 weeks. The G0 diet (control ...

Biochemical and genetic mechanisms of oxidative stress (OS) developing in blood patients with type 2 Diabetes mellitus (T2DM) were studied. Twenty T2DM 10 healthy persons participated this study. Lipid peroxidation, the content protein carbonyls H2O2 production measured plasma erythrocytes as OS biomarkers. Activity SOD, catalase, GPx well reduced glutathionе (GSH) level estimated. The gene exp...