Background and Objectives: The etiology, pathophysiology, nomenclature and clinical manifes-tation of solitary rectal ulcer syndrome (SRUS) is poorly understood. Aim: To examine the pathology of mucosal changes and clinical features of this syndrome. Materials and Methods: The mucosal biopsies of 19 pati...

High morbidity and mortality of influenza virus infection makes it an important disease world-wide. Mouse is a very well-studied animal model for this disease with similar manifestation to human disease. It would be desirable to induce mucosal as well as circulating immune responses to obtain protection from infection and to decrease the spread of the virus. Cell mediated immunity (proliferativ...

Statement of the problem: Nowadays leishmaniasis is a common infectious disease around the world which is caused by a protozoan parasite named Leishmania. This parasite is transmitted to human by an infected female sand fly. This disease has three clinical forms; mucosal forms are rare in Iran. Purpose: The purpose of this study was to report a case of leishmaniasis with lip and oral mucosal in...

background and objective: diagnosis of hirschsprung’s disease (hd) as the most common cause of neonatal intestinal obstruction is based on the presence of aganglionosis from seromuscular or full thickness biopsy. due to the complication of full thickness or seromuscular rectal biopsy, mucosal-sub mucosal biopsy is more intended. however, interpretation of these biopsies stained with hematoxylin...

crohn’s disease is an inflammatory bowel disease (ibd), characterized by chronic intestinal inflammation that causes the loss of immune tolerance leading to bizarre inflammatory signals and disruption of mucosal barriers. environmental triggers and interaction of genetic determinants also play an indispensible role. in this case report, we present a pre-pubertal girl with intermittent and refra...

background and objectives: the etiology, pathophysiology, nomenclature and clinical manifes-tation of solitary rectal ulcer syndrome (srus) is poorly understood. aim: to examine the pathology of mucosal changes and clinical features of this syndrome. materials and methods: the mucosal biopsies of 19 patients with clinical evidence of solitary rectal ulcer as been reviewed in accordance with the...

Focal epithelial hyperplasia or Heck’s disease is a benign, rare viral disease of the oral cavity and is associated with human papillomavirus 13 and 32 (HPV-13 and HPV-32). Most patients are children but adults may also be at risk. Clinically, the patients have multiple small white or pink papules on the mucosal surface of the lips, buccal mucosa and the tongue. In Iran, this disease seems to b...

lichen planus is a chronic inflammatory mucocutaneous disease. mucosal lesions are classified into six clinical forms and there is malignant potential for two forms of olp; therefore, follow-up should be considered. there are many un-established etiological factors for olp and some different treatment modalities are based on etiology. the aims of current olp therapy are to eliminate mucosal ery...