Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance the fields of organic and medicinal chemistry. Isatin, due its unique reactivity, can undergo different MCRs, affording multiple interesting scaffolds, namely oxindole-derivatives (including spirooxindoles, bis-oxindoles 3,3-disubstituted oxindoles) ...

In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certa...

A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses ...

Multicomponent reactions (MCRs) represent an ideal organic synthesis tool for the rapid construction of complex molecules due to their step and atom economy. Compared to two-component reactions, the development of new MCRs has been greatly limited during the 170 years since the first MCR was reported. Theoretically, the trapping of an active intermediate generated from two components by a third...

A mild and efficient one-pot three-component and environmentally benign approach for the synthesis of a wide range of hydantoin annulated derivatives has been described. A multi-component reaction between a carbonyl compounds (ketone or aldehyde), potassium cyanide and ammonium carbonate (as cyanating agent and amine source, respectively leads to the formation of hydantoins. The proposed optimi...

A novel multicomponent synthesis of ketene dithioacetal rhodanines has been reported by reactions of primary amine, carbon disulfide, ethyl chloroacetate, and alkyl halide in DMF. The catalytic effects of different bases have been investigated and potassium carbonate can efficiently catalyze the reaction in moderate to good yields at room temperature. 2013 Elsevier Ltd. All rights reserved. Mul...

Multicomponent reactions involving polyfunctional 4-amino-5-carboxamido-1,2,3-triazole and cyclic carbonyl-containing CH-acids were studied under conventional thermal heating, microwave and ultrasonic irradiation. The features of the reactions studied were discussed and the optimized procedures for the synthesis of final triazolopyrimidines were elaborated. In contrast to the similar MCRs of nu...

Multicomponent reactions (MCRs) are remarkable one-pot combinatorial synthetic tools involving at least three reactants whose nearly all atoms incorporated in the final product. The development of these high atom-efficient considerably raised level molecular complexity and diversity last decades. Nowadays, MCRs no longer confined to organic synthesis have seen their use extended polymer science...

Oxindole derivatives are known for their great interest in the field of Medicinal Chemistry, as they display vast biological activities. Recent efforts concerning preparation oxindole using isatin-based multicomponent reactions (MCRs) constitute a advance generating druglike libraries fast and with wide scaffold diversity. In this review, we address those recent developments, exploring syntheti...