Noting the progress made since 1991 towards achieving the international targets for 2005, the acceleration of efforts following the establishment of the Stop TB Partnership in response to resolution WHA51.13, and more recently following resolution WHA58.14 encouraging Member States to ensure availability of sufficient resources to achieve the internationally agreed goal relevant to tuberculosis...

amikacin has been shown to irreversibly suppresscochlear activity.the aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.in this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (mdr-tb) were included.all patients received fixed dose of intravenous amikacin(500 mg...

introduction: tuberculosis (tb) remains a deadly infectious disease despite all the efforts to reduce its incidence. spread of multidrug resistant tb has seriously undermined the efforts to control the disease globally. in this study protein expression profile of mdr and sensitive isolates of mtb were analyzed and compared in order to identify proteins, which could be used in prevention, diagno...

Background: Resistance of Mycobacterium Tuberculosis is a condition in which Anti-Tuberculosis (OAT) drugs are unable to kill the germs. One type resistance Multidrug Resistant Tuberculosis. (MDR-TB) TB caused by bacteria that resistant 2 types OAT, namely INH and Rifampin. The consequences if OAT deterioration health, increased costs, prolonged treatment, high rates therapy failure death.&#x0D...

Peng et al.[1] reported that the MDR‐TB burden among the new tuberculosis (TB) patients accounted for more than 1/4th of all multidrug‐resistant TB (MDR‐TB) cases in the past 5 years in Zhejiang province, although the identified rate of MDR‐TB among 9830 new TB cases was only 2.0%. Drug‐resistant TB, especially MDR‐TB, is a major threat to the control of TB worldwide. However, due to high cost ...

A young man presented with primary multi-drug resistant tuberculosis. The institution of second-line regimes with insufficient efficacy due to clinical inexperience, unreliable sensitivity reports and the inavailability of second-line drugs led to the development of an organism that was resistant to ten anti-tuberculous drugs. Accurate sensitivity testing done in an overseas laboratory enabled ...

Affiliations: Dept of Medicine and Office of Global Health, UT Southwestern Medical Center, Dallas, TX, and College of Pharmacy and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. Epidemiology and Medical Statistics Unit, Dept of Biomedical Sciences, University of Sassari–Research, Medical Education and Professional Development Unit, AOU Sassari, Sassari, and WHO Coll...

Affiliations: Dept of Infectious Diseases, Galliera Hospital, Genova, Italy. Clinical Epidemiology and Medical Statistics Unit, Dept of Biomedical Sciences University of Sassari – Research, Medical Education and Professional Development Unit, AOU Sassari, Sassari, Italy. WHO Collaborating Centre for TB and Lung Diseases, Fondazione S. Maugeri, Care and Research Institute, Tradate, Italy. Public...

In Africa, incidence and prevalence of drug-resistant tuberculosis have been assumed to be low. However, investigation after a 2005 outbreak of extensively drug-resistant tuberculosis in KwaZulu-Natal Province, South Africa, found that the incidence rate for multidrug-resistant tuberculosis in KwaZulu-Natal was among the highest globally and would be higher if case-finding efforts were intensif...