INTRODUCTION Multimodality therapy with chemotherapy and operative resection is recommended for patients with locoregional pancreatic cancer but is not received by many patients. OBJECTIVE To evaluate patterns in the use and timing of chemotherapy and resection and factors associated with receipt of multimodality therapy in older patients with locoregional pancreatic cancer. METHODS We used...

BACKGROUND Multimodality treatment of head and neck cancer in rural India is not always feasible due to lack of infrastructure and logistics. AIM To demonstrate the feasibility of multimodality treatment for head and neck cancer in a community setting in rural India. SETTING AND DESIGN Community cancer center, retrospective review. MATERIALS AND METHODS This article focuses on practice en...

Colorectal cancer is the third leading cause of cancer-related mortality in the world. The main cause of death because of colorectal cancer is hepatic metastases, which can be treated using isolated hepatic perfusion (IHP), allowing treatment of colorectal metastasis with various methods. In this study, we present a novel potent multimodality strategy comprising humanized death receptor 4 (DR4)...

Acromegaly is caused by excessive secretion of growth hormone (GH). The average annual incidence of acromegaly is approximately 3.3 per million, and the prevalence is approximately 60 per million (50). GH-secreting adenomas account for 20% of functional adenomas, and 75% of GH adenomas are macroadenomas (50). The mortality in untreated acromegaly is two to three times higher than that of the ge...

STUDY OBJECTIVES Malignant pleural mesothelioma (MPM) is predominantly a local/regional disease that results in a survival time that ranges from 4 to 12 months without treatment. Single-modality therapy using surgery, chemotherapy, or radiotherapy alone is largely ineffective. The objective of the study was presentation of the use of pleuropneumonectomy in a multimodality treatment setting and ...

BACKGROUND Desmoplastic small round cell tumor (DSRCT) is a rare malignant neoplasm of adolescent males. Current multimodality treatment prolongs life and rarely achieves cure. AIM To review the presenting features, histopathology and outcome of 18 patients with DSRCT treated at a single institution. SETTING AND DESIGN This is a retrospective observational study of patients with DSRCT who p...