Studies in both humans and rodents suggest that maternal diabetes leads to a higher risk of the fetus developing impaired glucose tolerance and obesity during adulthood. However, the impact of hyperinsulinemia in the mother on glucose homeostasis in the offspring has not been fully explored. We aimed to determine the consequences of maternal insulin resistance on offspring metabolism and endocr...

objective(s) during recent years, there has been an increasing interest in contribution of environmental pollutants as heavy metals to human male infertility. present study was aimed to investigate the effects of maternal lead acetate exposure during lactation on postnatal development of testis in offspring rats. materials and methods a total of 60 female rats randomly divided into four equal g...

BACKGROUND Ethnic groups differ significantly in adult physique and birth weight. We aimed to improve understanding of maternal versus paternal contributions to ethnic differences in birth weight, by comparing the offspring of same-ethnic versus mixed-ethnic unions amongst Europeans and South Asian Indians in the UK. METHODOLOGY AND PRINCIPAL FINDINGS We used data from the UK Office for Natio...

BACKGROUND Mothers bearing small offspring are at increased risk of cardiovascular disease (CVD) mortality. The cardiovascular risk for fathers of small offspring is, however, inconclusive. Very few studies with sufficiently large sample sizes have been conducted to specifically differentiate the maternal/paternal CVD risk in association with offspring birth weight in the same population. MET...

Research on mothers of twins suggests they have a more robust phenotype compared to singleton only mothers. Historical demographic microdata can be additional value in studying differences reproductive behaviour and survival their offspring between multiple birth However, the number such studies historical populations is limited. This study aims explore possibilities maternal life-histories usi...

Objective: To examine the possibility that low birth weight is a feature of the inherited predisposition to high blood pressure. Design: Cross sectional study. Setting: Primary care medical centre in Edinburgh. Subjects: One offspring of 452 families (231 men and 221 women aged 16-26 years) in whom blood pressure, weight, and height were measured in 1986 and whose parents had blood pressure mea...

Abstract Background The association between gestational diabetes mellitus (GDM) and childhood body weight remains controversial, additional study is needed, especially in Asian populations. Methods This prospective investigated the maternal glucose concentration, GDM status infant from birth to 12 months of age. Linear mixed effects (LME) models multiple linear regression were used assess longi...

CONTEXT Few systematic data exist on survival and reproduction among males with birth defects and their contribution to occurrence of birth defects in the next generation. OBJECTIVE To estimate survival of males with registered birth defects, their subsequent reproduction rates, and their risk of transmitting birth defects to their offspring. DESIGN AND SETTING Population-based cohort study...

OBJECTIVE To investigate any long term effects of traumatic birth and obstetric procedures in relation to suicide by violent means in offspring as adults. DESIGN Prospective case-control study. SETTING Stockholm, Sweden. SUBJECTS 242 adults who committed suicide by violent means from 1978 to 1995, and who were born in one of seven hospitals in Stockholm during 1945-80, matched with 403 bi...