NORMAL SKELETAL MUSCLE: C muscle cell = myocyte = muscle fiber = myofiber. C embryologically skeletal muscles are derived from paraxial mesoderm: P muscles of the back, body wall & limbs are derived from the myotome (ie part of mesodermal somites) & muscles of the head are from cranial paraxial mesoderm that migrates into the branchial arches. P the mesoderm differentiates into myoblasts ÿ alig...

Skeletal muscle is composed of elongated myofiber cells 1-40 mm long by 10-100 μm in diameter. Cells are multinucleated (100-300 nuclei/cell), non-branched with a parallel arrangement, and separated from each other by thin connective tissue (endomysium, perimysium, epimysium). The sarcolemmal membrane is formed by the endomysium and the basal lamina. The sarcoplasm of the myofibers has many myo...

Muscle and nerve biopsy may be vital diagnostic tools in various neuromuscular disorders. Since these procedures are invasive, it matters to decide when perform a biopsy, which muscle or selected, how interpret the pathologies. This review addresses indications, methods of biopsies, also significant pathological findings frequently encountered pathology.