A flame retardant used in children's sleepwear, tris-(1,3-dichloro-2-propyl)phosphate (Fyrol FR2) is a mutagen in the Salmonella-mammalian tissue homogenate test after it has been activated by mouse or rat liver homogenate. The expected enzymatic hydrolysis product, 1,3-dichloro-2-propanol, is similarly a mutagen after activation by liver homogenate. A proposed metabolite of the flame retardant...

Lymphocytic choriomeningitis virus (LCMV) has contributed to unveil some of the molecular mechanisms of lethal mutagenesis, or loss of virus infectivity due to increased mutation rates. Here we review these developments, and provide additional evidence that ribavirin displays a dual mutagenic and inhibitory activity on LCMV that can be relevant to treatment designs. Using 5-fluorouracil as muta...

We have generated a genomic phenotyping database identifying hundreds of Saccharomyces cerevisiae genes important for viable cellular recovery after mutagen exposure. Systematic phenotyping of 1,615 gene deletion strains produced distinctive signatures for each of four mutagens. Integration of the phenotyping database with mutagen-induced transcriptional profiling data demonstrated that being t...

This study evaluated the relationship between family history of cancer and bleomycin-induced mutagen sensitivity. The study included 108 patients who registered at The University of Texas M. D. Anderson Cancer Center from June 1987 to June 1991 with histologically confirmed and previously untreated squamous cell carcinoma of the upper aerodigestive tract. All patients underwent the mutagen sens...

Levels of bacterial mutagenicity 3-17 times above spontaneous are generated during commercial thermal processing (canning) of foods, particularly foods high in protein. The potential for other processing operations, including pasteurization, dehydration, and concentration, to produce substances active in the Ames Salmonella assay was also examined. Two heated fish model systems, canned salmon a...

The maize Adh1 gene is introduced, with citations. The use of this gene as a mutagen monitor is discussed, with emphasis on differentiating quantitative and qualitative parameters. A proper assessment of hazard from environmental pollutants requires data on possible mutagen specificities for different kinds of DNA.

Variability in DNA repair capability may be a determinant of interindividual difference in susceptibility to carcinogenic exposures. A cytogenetic assay which quantifies chromosomal breakage induced by in vitro exposure to a clastogen provides an indirect measure of repair. We report the results of a casecontrol study of upper aerodigestive trad cancers assessing differences in mutagen sensitiv...

Aim. To study the frequency and spectrum of cytogenetic disorders in Triticum aestivum L., induced by effect moderate high concentrations N-nitroso-N-methylurea. Methods. The seeds winter wheat cultivars Albatros odeskyi Zymoiarka were treated with water solution N-nitroso-N-methylurea such as 0.005 %, 0.01 0.025 %. A analysis cells a root meristem was made help an anatelophase method. Results....

Metaphors are powerful tools for sensemaking, sensegiving and theory development, but they are often concealed in academic writing. This paper uncovers two metaphors underlying entrepreneurship discourse and research – elixir and mutagen. The elixir metaphor is uncovered by examining critiques of entrepreneurship research and serves as a compact description of problematic aspects entrepreneursh...