Many factors including genetic, environmental, and acquired are involved in breast cancer development across various societies. Among all of these factors in families with a history of breast cancer throughout several generations, genetics, like predisposing genes to develop this disease, should be considered more. Early detection of mutation carriers in these genes, in turn, can play an import...

effects of induced mutation via gamma irradiated with 250 gy dose (in nuclear agriculture research school- nuclear science and technology research institute) on trichoderma harzianum conidiaon chitinase activity by sts molecular marker have been evaluated in this study. among 20 irradiated mutants which selected via improved antagonistic capability against rhizoctonia solani, pcr amplified chit...

Integration of the many available sources of cancer gene information--such as large-scale tumour-resequencing studies--identifies the 'usual suspect' genes, mutated in many tumour types, as well as different sets of mutated genes according to the specific tumour type. Scaling-up the analysis reveals that this large collection of mutated genes cluster into a smaller number of signalling pathways...

Technological advances in genome sequencing have led to the identification of novel driver genes mutated in renal cancer. Hitherto, 1 gene was known to be frequently mutated in renal cell carcinoma of clear cell type (ccRCC), the von Hippel-Lindau (VHL) gene. VHL was identified by positional cloning as the gene responsible for a familial syndrome with renal cancer predisposition, von Hippel-Lin...

BRCA1-mutated prostate cancer has been shown to be less responsive poly (ADP-ribose) polymerase (PARP) inhibitors as compared BRCA2-mutated cancer. The reason for this differential response is not clear. We hypothesized sensitivity PARP may explained by distinct genomic landscapes of BRCA1 versus BRCA2 co-segregating genes. Patients with advanced who underwent CGP cfDNA a CLIA-certified laborat...

A single cancer cell contains large numbers of genetic alterations that in combination create the malignant phenotype. However, whether amplified and mutated genes form functional and physical interaction networks that could explain the selection for cells with combined alterations is unknown. To investigate this issue, we characterized copy number alterations in 191 breast tumors using dense s...

We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific ex...