BACKGROUND An elevated interferon-gamma (IFN-gamma) level has been reported in the plasma of patients with pulmonary tuberculosis. Serologic diagnosis of tuberculosis using Antigen 60 immunoglobulin G (A60 IgG) is a well-known diagnostic approach. This study evaluated plasma IFN-y compared to A60 IgG in diagnosing Mycobacterium tuberculosis. METHODS This study recruited 65 patients with tuber...

Sir, Mycobacteria are known to have several immunologically active antigenic components like 38 Kd antigen, 30 Kd antigen, 16 Kd antigen, A60 antigen and lipoarabinomannan (LAM). 1 The MycoDot test is a new simple, rapid (20 minutes) and reliable serodiagnostic technique that can detect antimycobacterial antibodies in the serum or blood. It offers a low cost, single visit aid in the diagnosis o...

A60, the mouse monoclonal antibody against the neuronal nuclear protein (NeuN), is the most widely used neuronal marker in neuroscience research and neuropathological assays. Previous studies identified fragments of A60-immunoprecipitated protein as Synapsin I (Syn I), suggesting the antibody will demonstrate cross immunoreactivity. However, the likelihood of cross reactivity has never been ver...

BACKGROUND The identification of acid-fast bacilli (AFB) in sputum or tissue is the definite diagnosis of tuberculosis. However, this method of diagnosis is restricted by certain limitations. The serologic diagnosis of tuberculosis has been used for a long time. The aim of this study was to determine the sensitivity and specificity of Antigen 60 (A60) immunoglobulin G (IgG) in patients with abn...