Streptokinase is a potent fibrinolytic agent which is widely used in treatment of deep vein thrombosis (DVT), pulmonary embolism (PE) and acute myocardial infarction (MI). Major limitation of this enzyme is its short biological half-life in the blood stream. Our previous report showed that complexing streptokinase with chitosan could be a solution to overcome this limitation. The aim of this re...

Streptokinase is a potent fibrinolytic agent which is widely used in treatment of deep vein thrombosis (DVT), pulmonary embolism (PE) and acute myocardial infarction (MI). Major limitation of this enzyme is its short biological half-life in the blood stream. Our previous report showed that complexing streptokinase with chitosan could be a solution to overcome this limitation. The aim of this re...

conclusion: post-procedure hemoglobin dropping may be considered as a predictor of cardiac adverse outcome in patients undergoing pci. we suggest that a good bleeding control during and after the procedure can reduce the risk of cardiac enzyme elevation post-procedurally. results: all categories divided by cardiac enzyme status either in positive or in negative groups were classified in non-ane...

streptokinase is a potent fibrinolytic agent which is widely used in treatment of deep vein thrombosis (dvt), pulmonary embolism (pe) and acute myocardial infarction (mi). major limitation of this enzyme is its short biological half-life in the blood stream. our previous report showed that complexing streptokinase with chitosan could be a solution to overcome this limitation. the aim of this re...

Objective(s):The objective of this study was to investigate the interaction of daunorubicin (DNR) and cardiac myosin (CM) and the changes in mice hearts to exhibit DNR-induced cardiotoxicity . Materials and Methods:The interaction between DNR and CM was expressed using fluorescence quenching at pH 4.0-9.0 and 15-37 °C. DNR-induced cardiotoxicity was studied using in vivo experiment.  Forty grou...

stress-induced cardiomyopathy or takotsubo cardiomyopathy is a recently increasing diagnosed disease manifested by transient apical or mid left ventricular dilation and dysfunction. this sign is similar to acute myocardial infarction but without significant coronary artery stenosis. there are important and essential differences between takotsubo cardiomyopathy and acute myocardial infarction in...

We have shown earlier that cardiomyocyte apoptosis continues at a high level late after myocardial infarction and contributes to adverse cardiac remodeling. Here we studied whether this process can be inhibited by the vasopeptidase inhibitor omapatrilat, a drug which causes simultaneous inhibition of both angiotensin converting enzyme and neutral endopeptidase. Our hypothesis was that omapatril...

To investigate the effects of angiotensin converting enzyme 2 and genes on cardiac remodeling process in heart failure rats. 38 rats were randomly divided into sham-operated group (S group), (H group) exercise (HE group). An incremental load test was used to determine maximum running speed HE group, while S H groups maintained their daily activities. The structure function pathological changes ...

FOLLOWING tissue damage several tissue enzymes are released into the serum. On this basis, changes in serum glutamate-oxalacetate transaminase and lactate dehydrogenase have been used as indicators of the occurrence and severity of myocardial infarction. These tests lack specificity because damage to liver and other organs also causes an increase in the serum levels of these enzymes. Recently w...