In this paper we report the design, synthesis, antinociceptive and anti-inflammatory activities of a series of benzothiazine N-acylhydrazones 14a–h, planned by structural modification of piroxicam (1), a non steroidal anti-inflammatory drug. Among the synthesized analogues, compounds 14f (LASSBio-1637) and 14g (LASSBio-1639) were identified as novel antinociceptive and anti-inflammatory prototy...

Synthesis of dynamic combinatorial libraries acylhydrazones in the presence a G-quadruplex DNA template, followed by pull-down with streptavidin-coated magnetic beads, allows identification putative binders.

A facile catalytic one-pot synthesis of N-acylhydrazones via acceptorless dehydrogenative coupling readily available alcohols and benzohydrazides (R2CONHNH2) using arene ruthenium (II) complexes has been described. The with various catalysts provide a wide range in good to excellent yields (63–93%; 32 examples). present protocol offers high selectivity hydrazones without any alkylated products ...

A series of new N-acylhydrazone derivatives were synthesized in good yields through the reactions of dehydroabietic acid hydrazide with a variety of substituted arylaldehydes. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR, ESI-MS, elemental analysis and single crystal X-ray diffraction. From the crystal structure of compound 4l, the C=N double bonds of these ...