Microglia are the principal immune cells of the brain. In Alzheimer disease, these brain mononuclear phagocytes are recruited from the blood and accumulate in senile plaques. However, the role of microglia in Alzheimer disease has not been resolved. Microglia may be neuroprotective by phagocytosing amyloid-b (Ab), but their activation and the secretion of neurotoxins may also cause neurodegener...

The structure of the N-terminal region of mouse alpha-dystroglycan (DGN) was investigated by expression of two protein fragments (residues 30-180 and 30-438) in Escherichia coli cells. Trypsin susceptibility experiments show the presence of a stable alpha-dystroglycan N-terminal region (approximately from residue 30 to 315). In addition, guanidinium hydrochloride (Gdn/HCl) denaturation of DGN-(...

The aim of the study was to determine the effect of consuming meals with different fatty acid compositions on the postprandial changes over 6 h in plasma triacylglycerol, NEFA, total cholesterol, glucose and insulin concentrations in middle-aged men and women. Men (n 11; 58 (5) years) and women (n 11; 56 (4) years) consumed four test meals with a similar macronutrient energy content in random o...

Exhaled nitric oxide (NO) concentration is a noninvasive index for monitoring lung inflammation in diseases such as asthma. The plateau concentration at constant flow is highly dependent on the exhalation flow rate and the use of corticosteroids and cannot distinguish airway and alveolar sources. In subjects with steroid-naive asthma (n = 8) or steroid-treated asthma (n = 12) and in healthy con...

Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal anti-inflammatory agent that acts through the glucocorticoid receptor (GR) retains full anti-inflammatory efficacy but has reduced negative effects on osteoblasts compared to those elicited by prednisolone (Pred) or dexamethasone (Dex). We hav...

Recent Developments in the Study of Dental Caries: Scientific Apparatus and Laboratory Methods: DR. RUSSELL W. BUNTING ........................................ 419 Physiologically Balanced Culture Solutions with The Engineering Foundation: ALFRED D. FLINN ...... 424 Stable Hydrogen-ion Concentration: PROFESSOR SAM F. TRELEASE and HELEN M. TRELEASE ............ 438 Obituary: Dr. E. N. Lowe: D. C...

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2 Arguments Found in Legislative Instruments of Various Types ............ 438 2.1 Regulations of Various Types .................................................. 438 2.2 The Convention on the Rights of the Child .................................. 438 2.3 The Main Swedish Rules Dealing with Children and Advertising........ 439 2.4 The EC Rules ......................................................