The scope of the present work was to establish the role of the polymer charge on its ability to enhance the permeability of the urinary bladder wall. Cationic poly-L-arginine and chitosan, anionic sodium carboxymethyl cellulose (NaCMC) and alginate as well as nonionic hydroxypropyl cellulose (HPC) and hydroxypropyl methylcellulose (HPMC) were tested. The polymers were tested in concentrations f...

Metoprolol succinate (MS) gastroretentive (GR) controlled release system was formulated to increase gastric residence time leading to improved drug bioavailability. Box-Behnken model was followed using novel combinations of sodium alginate (SA), sodium carboxymethylcellulose (NaCMC), magnesium alumino metasilicate (MAS) as independent variables. Floating lag time (Flag), t25, t50, t75, diffusio...

Vaccine-mediated prevention of primary HIV-1 infection at the heterosexual mucosal portal of entry may be facilitated by highly optimised formulations or drug delivery devices for intravaginal (i.vag) immunization. Previously we described hydroxyethylcellulose (HEC)-based rheologically structured gel vehicles (RSVs) for vaginal immunization of an HIV-1 vaccine candidate, a soluble recombinant t...

        Controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (HPMC) as the matrix former. The effects of the viscosity grades of HPMC and HPMC/lactose ratio and ethylcellulose (EC)/sodium carboxymethylcellulose (NaCMC) and their concentrations on the release behavior of phenobarbital from HPMC matrices wer...

PURPOSE The objective of this work was to develop a bioadhesive topical gel of sertaconazole nitrate with the help of response-surface approach. METHODS Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Carbapol 934 = X1) and Sodium carboxymethylcellulose (NaCMC) = X2)] on the bioadhesive character of gel, rheolo...

The construction industry remains a significant contributor to global carbon emissions. Several sustainable alternatives have emerged overcome this issue in geotechnical engineering. In study, cellulose, an abundant biopolymer, is investigated for its potential modify properties favourably. Sodium carboxymethyl cellulose (NaCMC) anionic ether derivative of natural with good binding and moisture...

Purpose: To develop a safe mucoadhesive gel for nasal drug delivery using okra polysaccharide. Methods: Rizatriptan benzoate nasal gel was developed using natural polysaccharide obtained from the Abelmoschus esculentus. The gel formulation was characterized for pH, viscosity, mucoadhesion, and in vitro permeation. Permeation parameters obtained include drug flux (j), permeation coefficient (kP)...

Abstract Na + ion-conducting solid polymer electrolyte (SPE) of sodium salt carboxymethyl cellulose (NaCMC) doped with nitrate (NaNO 3 ) was developed by solution casting method. FTIR technique confirmed the formation hydrogen bonding between $$ {NO}_3^{-} NO 3 ? </mml:msub...

One of the disadvantages gel preparations is poor ability to penetrate skin. Herein we developed a sodium carboxymethylcellulose (NaCMC)-based containing microparticle doxycycline hyclate (DOX). Oleic acid (OA) was added into formulation specifically increase penetrability DOX microparticles. The objective this work determine effect varying concentration OA on physical characteristics, penetra...