OBJECTIVE To report clinical features, response to treatment, and long-term follow-up of nail lichen planus in children. DESIGN Retrospective study involving 15 children with nail lichen planus. SETTING Outpatient consultation for nail disorders at the Department of Dermatology of the University of Bologna, Bologna, Italy. PATIENTS OR OTHER PARTICIPANTS We diagnosed nail lichen planus in ...

The nail is a specialized keratinous skin appendage that grows approximately 2 to 3 mm per month, with complete replacement achieved in 6 to 9 months. Although this structure can be easily overlooked, nail disorders comprise approximately 10% of all dermatologic conditions. This contribution first provides an overview on the basic anatomy of the nail that will delineate between the nail unit (e...

Because nail psoriasis is difficult to treat, therapy with many biological drugs has been attempted. Ustekinumab is approved for chronic plaque psoriasis and psoriatic arthritis (PsA), with some trials reporting nail improvement using this agent. A 51-year-old man with severe chronic plaque psoriasis had severe involvement of all fingernails and toenails, with accompanying nail fold psoriasis. ...

Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders. In daily practice, dermoscopy may confirm clinical diagnoses and guides in the management of nail diseases and treatments, permitting a better visualization of symptoms. Dry dermoscopy is required for evaluation of the nail plate surface, while...

The nail unit is a dynamic complex which forms an important part of the integument. This complex consists of the nail matrix (NM), nail bed (NB), hyponychium, nail fold (NF) and the nail plate (NP). Cells of the nail matrix, under the protection of the proximal nail fold mature and keratinised to form the NP. The NM contributes to the most portion of the NP while about 10-15% is produced by the...

Regulation of adult stem cells (SCs) is fundamental for organ maintenance and tissue regeneration. On the body surface, different ectodermal organs exhibit distinctive modes of regeneration and the dynamics of their SC homeostasis remain to be unraveled. A slow cycling characteristic has been used to identify SCs in hair follicles and sweat glands; however, whether a quiescent population exists...

Examination and surgical intervention of nail unit lesions are often hindered by its natural hard keratinous nail plate. Knowledge of the basic anatomy of a nail unit and surgical pathology of a condition facilitate the delivery of an appropriate and effective treatment. The mild form of common ingrown toenail can be managed by tube insertion which entails inserting without anaesthesia a small ...

BACKGROUND Psoriasis is a chronic inflammatory skin disease that often progresses with nail alterations. It is suspected that there is a correlation between nail psoriasis and enthesitis of the distal interphalangeal joint, seeming to serve as a predictor. OBJECTIVES To analyze the profile of patients with nail psoriasis and correlate the presence of nail alterations with psoriatic arthritis,...