Selectively delivering anticancer drugs to solid tumors while avoiding their accumulation in healthy tissues is a major goal polymeric micelle research. We have recently discovered that the extravasation and permeation of micelles occur dynamic manner characterized by vascular bursts followed brief vigorous outward flow fluid (called “nano-eruptions”). Nano-eruptions allow delivery micelle-asso...

Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. C...

We examined the synthesis and characterization of polymer micelle using polymerizable cationic gemini surfactant (surfmer). Here, cationic gemini surfmer (GS) was newly synthesized and characterized. Also, a “monomer”-type surfmer (MS) was synthesized and characterized for comparison. The equilibrium properties in water and in the presence of 0.1 M NaBr were investigated by means of surface ten...

Structural transitions involving shape changes play an important role in cellular physiology. Such transition can be conveniently induced in charged micelles by increasing ionic strength of the medium. Shape changes have recently been shown to result in altered packing and lowering of micellar polarity. As a consequence of reduced polarity, the ionization states of micelle-bound molecules vary ...

A novel artificial peroxidase (AP) with highly catalytic efficiency was designed using hexadecyl trimethyl ammonium bromide (CTAB, 3 mM) nano-micelles and bovine heart cytochrome c (Cyt c, 0.5 µM) in 100 mM, pH 8.0 phosphate buffer at 25°C. The catalytic rate (kcat) and Michaelis-Menten (Km) of the AP were determined to be 0.311 ± 0.013 s(-1) and 8.64 ± 0.6 µM. The catalytic efficiency was 0.03...

In this investigation, a nano-sized protein-encapsulated polymeric micelle was prepared by self-assembling human serum albumin (HSA) as a model protein and degradable block copolymer methoxy poly(ethylene glycol)-poly(β-amino ester) (PEG-PAE) with piperidine and imidazole rings. From the zeta potential measurement, the protein-encapsulated polymeric micelle showed a pH-tuning charge conversion ...

As nano-scale drug delivery systems, smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are attractive. In this work, a biocompatible and pH-sensitive copolymer is synthesized through bridging poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) block and poly (D, L-lactide) (...

objective: diabetes mellitus is defined as a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both or insulin resistance. curcumin inhibits nf-κb signaling pathway. the aim of this study is evaluation of the effect of nano-curcumin on hba1c, fast blood glucose and lipid profile in diabetic patients. materials and methods:...

Amphiphilic block copolymer micelles have been the focus of research for the last decades because of the promising properties as nano size drug delivery vehicles. In polar aqueous milieu, copolymers self assemble into micelle structures which consist of hydrophilic corona and hydrophobic core regions. Space created inside the micelle core can be used for transportation of drug molecules of hydr...